2-氟-5-碘-3-硝基吡啶合成路线 （共 3 条）
反应条件
potassium fluoride in N,N-dimethyl-formamide
T=45°C; 18 h;
参考文献
Carroll, F. Ivy; Lee, Jeffrey R.; Navarro, Hernan A.; Ma, Wei; Brieaddy, Lawrence E.; Abraham, Philip; Damaj; Martin, Billy R.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 21 p. 4755 - 4761
反应条件
1.1: H5IO6; H2SO4; aq. AcOH / 0.25 h / 90 °C
1.2: 99 percent / I2 / 1 h
2.1: conc. HCl; NaNO2
2.2: 36 percent / CuCl
3.1: 89 percent / KF / dimethylformamide / 18 h / 45 °C
View Scheme
参考文献
Carroll, F. Ivy; Lee, Jeffrey R.; Navarro, Hernan A.; Ma, Wei; Brieaddy, Lawrence E.; Abraham, Philip; Damaj; Martin, Billy R.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 21 p. 4755 - 4761
反应条件
1.1: conc. HCl; NaNO2
1.2: 36 percent / CuCl
2.1: 89 percent / KF / dimethylformamide / 18 h / 45 °C
View Scheme
参考文献
Carroll, F. Ivy; Lee, Jeffrey R.; Navarro, Hernan A.; Ma, Wei; Brieaddy, Lawrence E.; Abraham, Philip; Damaj; Martin, Billy R.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 21 p. 4755 - 4761
