2,4,6-trichloro-1,3,5-triazine in N,N-dimethyl-formamide T=20°C; 0.333333 h;

1: With diethylamino-sulfur trifluoride in dichloromethane T=-30 - 20°C; Inert atmosphere; 2: With sodium carbonate in dichloromethane; water T=20°C; pH=7;

pyridine; 1H-imidazole T=-5 - 0°C; 0.416667 - 0.5 h; Product distribution / selectivity;

1: sodium hydrogencarbonate / 1,4-dioxane; water / 24 h / 20 °C 2: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / |Inert atmosphere 3: lithium hydroxide hydrate / 1,4-dioxane; water / 3 h / 20 °C 4: ammonium hydrogen carbonate; pyridine / 1,4-dioxane / 6 h / 20 °C 5: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme

1: sodium hydrogencarbonate / 1,4-dioxane; water / 24 h / 20 °C 2: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / |Inert atmosphere 3: lithium hydroxide hydrate / 1,4-dioxane; water / 3 h / 20 °C 4: ammonium hydrogen carbonate; pyridine / 1,4-dioxane / 6 h / 20 °C 5: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme

1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / |Inert atmosphere 2: lithium hydroxide hydrate / 1,4-dioxane; water / 3 h / 20 °C 3: ammonium hydrogen carbonate; pyridine / 1,4-dioxane / 6 h / 20 °C 4: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme

1: lithium hydroxide hydrate / 1,4-dioxane; water / 3 h / 20 °C 2: ammonium hydrogen carbonate; pyridine / 1,4-dioxane / 6 h / 20 °C 3: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme

1: ammonium hydrogen carbonate; pyridine / 1,4-dioxane / 6 h / 20 °C 2: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme