4-甲氧基-9H-芴-9-酮合成路线 （共 12 条）
反应条件
cesium fluoride; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium(0) in toluene; acetonitrile
T=110°C; 12 h;
参考文献
Zhang, Xiaoxia; Larock, Richard C.
Organic Letters, 2005 , vol. 7, # 18 p. 3973 - 3976
反应条件
1: With potassium hydroxide
T=90°C; Rearrangement; 1 h;
2: With lead(IV) acetate in benzene
T=20°C; oxidative decarboxylation;
参考文献
Fu, Jian-Min; Snieckus, Victor
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 905 - 919
反应条件
sodium hydroxide in ethanol
0.5 h; Heating;
参考文献
Zeng, Wei; Eric Ballard; Tkachenko, Alexander G.; Burns, Virginia A.; Feldheim, Daniel L.; Melander, Christian
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5148 - 5151
反应条件
potassium hydroxide in dimethyl sulfoxide
T=20°C;
参考文献
Dei; Teodori; Garnier-Suillerot; Gualtieri; Scapecchi; Budriesi; Chiarini
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 10 p. 2673 - 2682
反应条件
in acetonitrile
36 h; Irradiation;
参考文献
Moorthy, Jarugu Narasimha; Samanta, Subhas
Journal of Organic Chemistry, 2007 , vol. 72, # 25 p. 9786 - 9789
反应条件
1: 73 percent / H2SO4; aq. NaNO2
2: 95 percent / aq. NaOH / ethanol / 0.5 h / Heating
View Scheme
参考文献
Zeng, Wei; Eric Ballard; Tkachenko, Alexander G.; Burns, Virginia A.; Feldheim, Daniel L.; Melander, Christian
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5148 - 5151
反应条件
1.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 1 h / -78 °C
1.2: tetrahydrofuran; cyclohexane / 4 h / 40 °C
1.3: 96 percent / aq. HCl; NH4Cl / tetrahydrofuran; cyclohexane / 1 h / -40 - 20 °C
2.1: 78 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / Heating
3.1: 92 percent / LDA / tetrahydrofuran / 20 °C
4.1: 99 percent / O2; salcomine / dimethylformamide / 4 h / 20 °C
5.1: aq. KOH / 1 h / 90 °C
5.2: 99 percent / Pb(OAc)4 / benzene / 20 °C
View Scheme
参考文献
Fu, Jian-Min; Snieckus, Victor
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 905 - 919
反应条件
1.1: 78 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / Heating
2.1: 92 percent / LDA / tetrahydrofuran / 20 °C
3.1: 99 percent / O2; salcomine / dimethylformamide / 4 h / 20 °C
4.1: aq. KOH / 1 h / 90 °C
4.2: 99 percent / Pb(OAc)4 / benzene / 20 °C
View Scheme
参考文献
Fu, Jian-Min; Snieckus, Victor
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 905 - 919
反应条件
1.1: 99 percent / O2; salcomine / dimethylformamide / 4 h / 20 °C
2.1: aq. KOH / 1 h / 90 °C
2.2: 99 percent / Pb(OAc)4 / benzene / 20 °C
View Scheme
参考文献
Fu, Jian-Min; Snieckus, Victor
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 905 - 919
反应条件
1.1: 92 percent / LDA / tetrahydrofuran / 20 °C
2.1: 99 percent / O2; salcomine / dimethylformamide / 4 h / 20 °C
3.1: aq. KOH / 1 h / 90 °C
3.2: 99 percent / Pb(OAc)4 / benzene / 20 °C
View Scheme
参考文献
Fu, Jian-Min; Snieckus, Victor
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 905 - 919
