反应条件
1.1: lithium hydride / tetrahydrofuran / 0.5 h / 40 - 45 °C / |Inert atmosphere; |Large scale
1.2: 5.3 h / 40 °C / |Inert atmosphere; |Large scale
1.3: 2 h / 25 - 30 °C / |Inert atmosphere; |Large scale
2.1: triethylamine; thionyl chloride / toluene; tert-butyl methyl ether / 1.75 h / 0 - 23 °C / |Large scale
3.1: tetra(n-butyl)ammonium hydrogensulfate; sodium azide / toluene; tert-butyl methyl ether; water / 23 °C / |Large scale
4.1: toluene / 1 h / 90 - 100 °C
5.1: toluene; tert-butyl alcohol / 1.67 h / 0 - 23 °C / |Large scale
5.2: 20 - 30 °C / |Large scale
View Scheme
参考文献
Varie, David L.; Beck, Christopher; Borders, Sandra K.; Brady, Molly D.; Cronin, Jason S.; Ditsworth, Tracy K.; Hay, David A.; Hoard, David W.; Hoying, Richard C.; Linder, Ryan J.; Miller, Richard D.; Moher, Eric D.; Remacle, Jacob R.; Rieck III, John A.; Anderson, David D.; Dodson, Paul N.; Forst, Mindy B.; Pierson, Duane A.; Turpin, Joseph A.
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 546 - 559
