3-苯基-1H-吡唑并[3,4-d]嘧啶-4-胺合成路线 （共 7 条）
参考文献
Kumar, Anil; Ahmad, Israr; Chhikara, Bhupender S.; Tiwari, Rakesh; Mandal, Deendayal; Parang, Keykavous
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1342 - 1346
反应条件
1: 75 percent / hydrazine hydrochloride; triethylamine / ethanol / Heating
2: 72 percent / 180 °C
View Scheme
参考文献
Kraybill, Brian C.; Elkin, Lisa L.; Blethrow, Justin D.; Morgan, David O.; Shokat, Kevan M.
Journal of the American Chemical Society, 2002 , vol. 124, # 41 p. 12118 - 12128
反应条件
1: 84 percent / aq. NaHCO3 / dioxane / Heating
2: 75 percent / hydrazine hydrochloride; triethylamine / ethanol / Heating
3: 72 percent / 180 °C
View Scheme
参考文献
Kraybill, Brian C.; Elkin, Lisa L.; Blethrow, Justin D.; Morgan, David O.; Shokat, Kevan M.
Journal of the American Chemical Society, 2002 , vol. 124, # 41 p. 12118 - 12128
反应条件
1.1: NaH / tetrahydrofuran / 0 °C
1.2: 81 percent / tetrahydrofuran / 0 - 20 °C
2.1: 84 percent / aq. NaHCO3 / dioxane / Heating
3.1: 75 percent / hydrazine hydrochloride; triethylamine / ethanol / Heating
4.1: 72 percent / 180 °C
View Scheme
参考文献
Kraybill, Brian C.; Elkin, Lisa L.; Blethrow, Justin D.; Morgan, David O.; Shokat, Kevan M.
Journal of the American Chemical Society, 2002 , vol. 124, # 41 p. 12118 - 12128
反应条件
1: sodium hydrogencarbonate / 1,4-dioxane
2: hydrazine monohydrochloride; triethylamine
3: 24 h / 180 °C
View Scheme
参考文献
Kumar, Anil; Ahmad, Israr; Chhikara, Bhupender S.; Tiwari, Rakesh; Mandal, Deendayal; Parang, Keykavous
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1342 - 1346
反应条件
1: K2CO3 / CH2Cl2 / 24 h / Ambient temperature
2: 74 percent / hydrazine hydrate / 1 h / 100 °C
3: 53 percent / 2 h / 200 °C
View Scheme
参考文献
Tominaga, Yoshinori; Matsuoka, Yoshiki; Oniyama, Yukio; Uchimura, Yoshimitsu; Komiya, Hirofumi; et al.
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 647 - 660
反应条件
1: 74 percent / hydrazine hydrate / 1 h / 100 °C
2: 53 percent / 2 h / 200 °C
View Scheme
参考文献
Tominaga, Yoshinori; Matsuoka, Yoshiki; Oniyama, Yukio; Uchimura, Yoshimitsu; Komiya, Hirofumi; et al.
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 647 - 660
