4,6-二氯-1H-吡唑并[3,4-C]嘧啶合成路线 (共 17 条)
反应条件
triethylamine; hydrazine in methanol T=-10°C; 2 h;
参考文献
TANABE SEIYAKU CO., LTD.
Patent: EP1772454 A1, 2007 ;
Location in patent: Page/Page column 58 ;
EP 1772454 A1
反应条件
N,N-diethylaniline; trichlorophosphate
参考文献
GATEKEEPER PHARMACEUTICAL, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun
Patent: WO2011/79231 A1, 2011 ;
Location in patent: Page/Page column 89 ;
反应条件
N,N-diethylaniline; trichlorophosphate T=90 - 100°C; 5 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/62805 A1, 2007 ;
Location in patent: Page/Page column 71 ;
WO 2007/062805 A1
反应条件
triethylamine in ethanol; dichloromethane
参考文献
Richard, David J.; Verheijen, Jeroen C.; Curran, Kevin; Kaplan, Joshua; Toral-Barza, Lourdes; Hollander, Irwin; Lucas, Judy; Yu, Ker; Zask, Arie
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6830 - 6835
反应条件
1: aqueous KOH 2: ethanol; NH3 / 200 °C View Scheme
参考文献
Robins
Journal of the American Chemical Society, 1957 , vol. 79, p. 6407,6412
参考文献
Robins
Journal of the American Chemical Society, 1957 , vol. 79, p. 6407,6412
反应条件
1: NaHS; water
2: water
View Scheme
参考文献
Robins
Journal of the American Chemical Society, 1957 , vol. 79, p. 6407,6412
反应条件
1: methanol.KOH
2: water
View Scheme
参考文献
Robins
Journal of the American Chemical Society, 1957 , vol. 79, p. 6407,6412
反应条件
sodium hydrogensulfide; water
参考文献
Robins
Journal of the American Chemical Society, 1957 , vol. 79, p. 6407,6412
参考文献
Robins
Journal of the American Chemical Society, 1957 , vol. 79, p. 6407,6412