1,2,3,4-四氢-2,4-二氧代-5-嘧啶羧酸甲酯合成路线 （共 10 条）
反应条件
ammonium hydroxide T=60°C;
参考文献
Miyashita; Matsumura; Kasahara; Shimadzu; Hashimoto
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 3 p. 887 - 898
反应条件
in 2,4-dimethylbutane; trichlorophosphate
参考文献
Astra Pharmaceuticals Limited
Patent: US6107297 A1, 2000 ;
反应条件
hydrogenchloride in water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4329460 A1, 1982 ;
反应条件
thionyl chloride
18 h; Reflux;
参考文献
Accetta, Alessandro; Corradini, Roberto; Sforza, Stefano; Tedeschi, Tullia; Brognara, Eleonora; Borgatti, Monica; Gambari, Roberto; Marchelli, Rosangela
Journal of Medicinal Chemistry, 2009 , vol. 52, # 1 p. 87 - 94
反应条件
1: 83 percent / K2S2O8 / AgNO3 / H2O / 40 - 45 °C
2: 70 percent / K2S2O8 / AgNO3 / H2O / 0.5 h / Heating
3: 86 percent / HCl gas / 12 h / Heating
View Scheme
参考文献
Hudson, Robert H. E.; Wojciechowski, Filip
Canadian Journal of Chemistry, 2005 , vol. 83, # 10 p. 1731 - 1740
反应条件
1: 70 percent / K2S2O8 / AgNO3 / H2O / 0.5 h / Heating
2: 86 percent / HCl gas / 12 h / Heating
View Scheme
参考文献
Hudson, Robert H. E.; Wojciechowski, Filip
Canadian Journal of Chemistry, 2005 , vol. 83, # 10 p. 1731 - 1740
参考文献
Wheeler; Johnson; Johns
American Chemical Journal, 1907 , vol. 37, p. 396
反应条件
in methanol; monofluoro-trichloromethane
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4329460 A1, 1982 ;
反应条件
1: 81 percent / F2
2: 93 percent / pyridine / 3 h / 65 - 75 °C
View Scheme
参考文献
Miyashita; Matsumura; Kasahara; Shimadzu; Hashimoto
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 3 p. 887 - 898
参考文献
Miyashita; Matsumura; Kasahara; Shimadzu; Hashimoto
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 3 p. 887 - 898
