5-甲基异恶唑-4-甲酸合成路线 （共 10 条）
反应条件
sulfuric acid in o-tolyl acetic acid
参考文献
Ray, Anup Kumar; Patel, Hiren Kumar V.; Patel, Mahendra R.
Patent: US2003/139606 A1, 2003 ;
反应条件
1: 84 percent / NH2OH*HCl / methanol / 1 h / Heating 2: 55 percent / conc.HCl, AcOH / 1 h / Heating View Scheme
参考文献
Schenone, Pietro; Fossa, Paola; Menozzi, Giulia
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 2 p. 453 - 457
反应条件
1: 350 g / hydroxylamine hydrochloride, sodium acetate trihydrate / ethanol; H2O / 0 °C 2: 270 g / conc. HCl / acetic acid; H2O / 10 h / Heating View Scheme
参考文献
Doleschall, Gabor; Seres, Peter
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 1875 - 1880
反应条件
potassium dichromate; sulfuric acid
参考文献
Kotschetkow et al.
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 2736,2743; engl. Ausg. S. 2762, 2768
反应条件
1: ethanol; NH2OH+HCl 2: aqueous H2SO4 View Scheme
参考文献
Yasuda
Yakugaku Zasshi, 1959 , vol. 79, p. 836
Chem.Abstr., 1960 , p. 1493
反应条件
1: 96 percent / SOCl2 / 1 h / 70 °C 2: 93 percent / diethyl ether / 0.5 h / Ambient temperature View Scheme
参考文献
Dai, Jian-Jun; Fang, Chi; Xiao, Bin; Yi, Jun; Xu, Jun; Liu, Zhao-Jing; Lu, Xi; Liu, Lei; Fu, Yao
Journal of the American Chemical Society, 2013 , vol. 135, # 23 p. 8436 - 8439
反应条件
1: 5-methyl-1,2-oxazole-4-carboxylic acid With 1,1'-carbonyldiimidazole in neat (no solvent) 0.333333 h; Milling; 2: 4-(trifluoromethyl)aniline hydrochloride in neat (no solvent) 5 h; Milling;
参考文献
Metro, Thomas-Xavier; Bonnamour, Julien; Reidon, Thomas; Sarpoulet, Jordi; Martinez, Jean; Lamaty, Frederic
Chemical Communications, 2012 , vol. 48, # 96 p. 11781 - 11783
反应条件
thionyl chloride in toluene
参考文献
Avrutov, Ilya; Gershon, Neomi; Liberman, Anita
Patent: US2002/22646 A1, 2002 ;
参考文献
Hoechst Aktiengesellschaft
Patent: US5977151 A1, 1999 ;
反应条件
1: 96 percent / SOCl2 / 1 h / 70 °C
2: 44 percent / diethyl ether / 0.5 h / Ambient temperature
View Scheme
参考文献
Fossa; Menozzi; Schenone; Filipelli; Russo; Lucarelli; Marmo
Farmaco, 1991 , vol. 46, # 6 p. 789 - 802
