2,3-二甲氧基氧杂蒽-9-酮合成路线 （共 17 条）
反应条件
cesium fluoride in tetrahydrofuran
T=90°C; 24 h;
参考文献
Zhao, Jian; Larock, Richard C.
Organic Letters, 2005 , vol. 7, # 19 p. 4273 - 4275
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Zhao, Jian; Larock, Richard C.
Journal of Organic Chemistry, 2007 , vol. 72, # 2 p. 583 - 588
反应条件
1: With AlCl3, aluminium chloride in 1,2-dichloro-ethane
T=0 - 20°C; Inert atmosphereReflux;
2: With sodium ethanolate in ethanol
3 h; RefluxInert atmosphere;
参考文献
Qu, Da-Hui; Feringa, Ben L.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 6 p. 1107 - 1110
参考文献
Pedro, Madalena; Cerqueira, Fatima; Sousa, Maria Emilia; Nascimento, Maria Sao Jose; Pinto, Madalena
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 12 p. 3725 - 3730
反应条件
1: oxalyl chloride / benzene / 2 h / Ambient temperature
2: 1.) AlCl3, 2.) pyridine, tetramethylammonium hydroxide / 1.) Et2O, RT, 8 h, 2.) H2O, reflux, 36 h
View Scheme
参考文献
Lin; Liou; Ko; Teng
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 1 p. 11 - 16
反应条件
1: Cu; K2CO3 / pyridine / 26 h / Heating
2: NaOH / methanol; tetrahydrofuran; H2O / 96 h / 20 °C
3: AcCl; H2SO4 / 0.17 h / 20 °C
View Scheme
参考文献
Sousa, Emilia P.; Silva, Artur M. S.; Pinto, Madalena M. M.; Pedro, Madalena M.; Cerqueira, Fatima A. M.; Nascimento, Maria S. J.
Helvetica Chimica Acta, 2002 , vol. 85, # 9 p. 2862 - 2876
反应条件
1: Cu; K2CO3 / pyridine / 26 h / Heating
2: NaOH / methanol; tetrahydrofuran; H2O / 96 h / 20 °C
3: AcCl; H2SO4 / 0.17 h / 20 °C
View Scheme
参考文献
Sousa, Emilia P.; Silva, Artur M. S.; Pinto, Madalena M. M.; Pedro, Madalena M.; Cerqueira, Fatima A. M.; Nascimento, Maria S. J.
Helvetica Chimica Acta, 2002 , vol. 85, # 9 p. 2862 - 2876
反应条件
1: NaOH / methanol; tetrahydrofuran; H2O / 96 h / 20 °C
2: AcCl; H2SO4 / 0.17 h / 20 °C
View Scheme
参考文献
Sousa, Emilia P.; Silva, Artur M. S.; Pinto, Madalena M. M.; Pedro, Madalena M.; Cerqueira, Fatima A. M.; Nascimento, Maria S. J.
Helvetica Chimica Acta, 2002 , vol. 85, # 9 p. 2862 - 2876
反应条件
1: tetra-n-butylammonium difluorotriphenylsilicate(IV) / toluene / 24 h / 60 °C
2: potassium carbonate / acetonitrile / 24 h / 100 °C
View Scheme
参考文献
Dubrovskiy, Anton V.; Larock, Richard C.
Tetrahedron, 2013 , vol. 69, # 13 p. 2789 - 2798
反应条件
pyridine; aluminium trichloride; tetreamethyl ammonium hydroxide
1.) Et2O, RT, 8 h, 2.) H2O, reflux, 36 h; Yield given. Multistep reaction;
参考文献
Lin; Liou; Ko; Teng
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 1 p. 11 - 16
反应条件
aluminium trichloride; nitrobenzene
参考文献
Kimoto et al.
Yakugaku Zasshi, 1953 , vol. 73, p. 506
Chem.Abstr., 1954 , p. 3354
