1: (E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester With lithium hexamethyldisilazane in tetrahydrofuran T=-35°C; 1.5 h; 2: 2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one With 4-(N,N-diethylamino)-toluene in tetrahydrofuran T=-40 - -35°C; 3 h; 3: With acetic acid in tetrahydrofuran pH=5 - 7; 6 h; Heating;

n-butyllithium; sodium hydrogencarbonate; acetic acid in tetrahydrofuran; ethanol; n-heptane; dichloromethane

1.1: LHMDS / tetrahydrofuran / 2 h / -30 °C 1.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C / pH 7 2.1: acetic acid / tetrahydrofuran / pH 5 / Heating View Scheme