(R)-甲基吡咯烷-3-甲酯盐酸盐合成路线 （共 5 条）
反应条件
hydrogen; palladium dihydroxide in methanol
T=20°C;
参考文献
Felluga, Fulvia; Pitacco, Giuliana; Prodan, Massimo; Pricl, Sabrina; Visintin, Marco; Valentin, Ennio
Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3241 - 3249
反应条件
1.1: α-chymotrypsine (α-CT) / aq. phosphate buffer / 20 °C / pH 7.4 / low conversion
2.1: BH3-DMS / tetrahydrofuran / -10 - 20 °C
2.2: 64 percent / aq. HCl / tetrahydrofuran; methanol / 1 h / Heating
3.1: 95 percent / H2 / 20 percent Pd(OH)2/C / methanol / 20 °C
View Scheme
参考文献
Felluga, Fulvia; Pitacco, Giuliana; Prodan, Massimo; Pricl, Sabrina; Visintin, Marco; Valentin, Ennio
Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3241 - 3249
反应条件
1.1: 85 percent / methanol / 12 h / 20 °C
2.1: α-chymotrypsine (α-CT) / aq. phosphate buffer / 20 °C / pH 7.4 / low conversion
3.1: BH3-DMS / tetrahydrofuran / -10 - 20 °C
3.2: 64 percent / aq. HCl / tetrahydrofuran; methanol / 1 h / Heating
4.1: 95 percent / H2 / 20 percent Pd(OH)2/C / methanol / 20 °C
View Scheme
参考文献
Felluga, Fulvia; Pitacco, Giuliana; Prodan, Massimo; Pricl, Sabrina; Visintin, Marco; Valentin, Ennio
Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3241 - 3249
反应条件
1.1: BH3-DMS / tetrahydrofuran / -10 - 20 °C
1.2: 64 percent / aq. HCl / tetrahydrofuran; methanol / 1 h / Heating
2.1: 95 percent / H2 / 20 percent Pd(OH)2/C / methanol / 20 °C
View Scheme
参考文献
Felluga, Fulvia; Pitacco, Giuliana; Prodan, Massimo; Pricl, Sabrina; Visintin, Marco; Valentin, Ennio
Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3241 - 3249
反应条件
sodium cyanoborohydride in methanol; water
1) -20 deg C to r.t., 1 h, 2) r.t., 20 h; Yield given;
参考文献
Thomas; Ohnmacht; Zahn; Mohr; Gmeiner, Peter
Pharmazie, 1999 , vol. 54, # 4 p. 248 - 250
