dilithium tetrachlorocuprate; ethylmagnesium bromide 1.) THF, 40-50 deg C, 2.) THF, HMPA, from -70 deg C to 0 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Cheskis, B. A.; Ivanova, N. M.; Moiseenkov, A. M.; Nefedov, O. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1991 , vol. 40, # 7 p. 1372 - 1380
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1991 , # 7 p. 1555 - 1562
1.1: 92 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 5 h / 20 °C 2.1: Mg / tetrahydrofuran / 20 °C 2.2: Li2CuCl4 / tetrahydrofuran / -78 °C 2.3: 64 percent / tetrahydrofuran / 15 h / -78 - 20 °C View Scheme
参考文献
Pinchuk, Anatoly N.; Rampy, Mark A.; Longino, Marc A.; Skinner, R. W. Scott; Gross, Milton D.; Weichert, Jamey P.; Counsell, Raymond E.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2155 - 2165