2-[4-氯-2-(氯甲基)苯氧基]乙酸合成路线 （共 6 条）
反应条件
hydrogenchloride; phosphoric acid; acetic acid in water
T=90°C; 18 h; Inert atmosphere;
参考文献
Belecki, Katherine; Berliner, Martin; Bibart, Richard Todd; Meltz, Cliff; Ng, Karl; Phillips, James; Ripin, David H. Brown; Vetelino, Michael
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 754 - 761
反应条件
hydrogenchloride; acetic acid
参考文献
Newman; Fones; Renoll
Journal of the American Chemical Society, 1947 , vol. 69, p. 718,721
反应条件
1: ZnCl2; HCl / 60 °C
2: concentrated aqueous HCl; glacial acetic acid
View Scheme
参考文献
Newman; Fones; Renoll
Journal of the American Chemical Society, 1947 , vol. 69, p. 718,721
反应条件
1: potassium phosphate / acetone / 10 h / 40 - 60 °C / |Reflux; |Inert atmosphere
2: acetic acid; hydrogenchloride; phosphoric acid / water / 18 h / 90 °C / |Inert atmosphere
View Scheme
参考文献
Belecki, Katherine; Berliner, Martin; Bibart, Richard Todd; Meltz, Cliff; Ng, Karl; Phillips, James; Ripin, David H. Brown; Vetelino, Michael
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 754 - 761
参考文献
Bulanova,N.P. et al.
Journal of Organic Chemistry USSR (English Translation), 1967 , vol. 3, p. 339 - 342
Zhurnal Organicheskoi Khimii, 1967 , vol. 3, # 2 p. 355 - 357
反应条件
(i) NaOAc, AcOH, (ii) aq. KOH; Multistep reaction;
参考文献
Bulanova,N.P. et al.
Journal of Organic Chemistry USSR (English Translation), 1967 , vol. 3, p. 339 - 342
Zhurnal Organicheskoi Khimii, 1967 , vol. 3, # 2 p. 355 - 357
