二乙基乙酰氨基(3-氟-4,5-二甲氧基苄基)丙二酸酯合成路线 （共 7 条）
反应条件
1: 90 percent / NaBH4 / tetrahydrofuran / 1 h / 40 - 60 °C
2: 93 percent / conc. HCl / 0.67 h / Heating
3: 85 percent / t-BuOK / dimethylformamide / 2 h / 120 °C
4: 99percent hydrazine hydrate / 5percent Ru/C / aq. ethanol / 24 h / Heating
View Scheme
参考文献
Argentini, Mario; Wiese, Claudia; Weinreich, Regin
Journal of Fluorine Chemistry, 1994 , vol. 68, # 2 p. 141 - 144
反应条件
1: 85 percent / t-BuOK / dimethylformamide / 2 h / 120 °C
2: 99percent hydrazine hydrate / 5percent Ru/C / aq. ethanol / 24 h / Heating
View Scheme
参考文献
Argentini, Mario; Wiese, Claudia; Weinreich, Regin
Journal of Fluorine Chemistry, 1994 , vol. 68, # 2 p. 141 - 144
反应条件
1: 99percent hydrazine hydrate / 5percent Ru/C / aq. ethanol / 24 h / Heating
View Scheme
参考文献
Argentini, Mario; Wiese, Claudia; Weinreich, Regin
Journal of Fluorine Chemistry, 1994 , vol. 68, # 2 p. 141 - 144
反应条件
1: 93 percent / conc. HCl / 0.67 h / Heating
2: 85 percent / t-BuOK / dimethylformamide / 2 h / 120 °C
3: 99percent hydrazine hydrate / 5percent Ru/C / aq. ethanol / 24 h / Heating
View Scheme
参考文献
Argentini, Mario; Wiese, Claudia; Weinreich, Regin
Journal of Fluorine Chemistry, 1994 , vol. 68, # 2 p. 141 - 144
反应条件
1: (i) aq. KOH, (ii) /BRN= 635994/
2: NaBH4 / tetrahydrofuran
3: aq. HCl
4: NaOEt
5: H2 / Pd-C / acetic acid
6: (i) NaNO2, aq. HCl, (ii) aq. HBF4
7: xylene / 132 °C
View Scheme
参考文献
Firnau,G. et al.
Journal of Medicinal Chemistry, 1973 , vol. 16, p. 416 - 418
反应条件
Yield given. Multistep reaction;
参考文献
Argentini, Mario; Wiese, Claudia; Weinreich, Regin
Journal of Fluorine Chemistry, 1994 , vol. 68, # 2 p. 141 - 144
反应条件
hydrogen bromide
2 h; Heating;
参考文献
Argentini, Mario; Wiese, Claudia; Weinreich, Regin
Journal of Fluorine Chemistry, 1994 , vol. 68, # 2 p. 141 - 144
