3-(1H-苯并咪唑-2-基)-2-甲基-苯胺合成路线 （共 4 条）
反应条件
10 palladium on activated carbon; hydrogen in methanol; ethanol; ethyl acetate
T=20°C; 3 h;
参考文献
Keurulainen, Leena; Salin, Olli; Siiskonen, Antti; Kern, Jan Marco; Alvesalo, Joni; Kiuru, Paula; Maass, Matthias; Yli-Kauhaluoma, Jari; Vuorela, Pia
Journal of Medicinal Chemistry, 2010 , vol. 53, # 21 p. 7664 - 7674
反应条件
1: toluene-4-sulfonic acid / para-xylene / 18 h / 140 °C / Inert atmosphere
2: 10 palladium on activated carbon; hydrogen / methanol; ethanol; ethyl acetate / 3 h / 20 °C
View Scheme
参考文献
Keurulainen, Leena; Salin, Olli; Siiskonen, Antti; Kern, Jan Marco; Alvesalo, Joni; Kiuru, Paula; Maass, Matthias; Yli-Kauhaluoma, Jari; Vuorela, Pia
Journal of Medicinal Chemistry, 2010 , vol. 53, # 21 p. 7664 - 7674
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1.5 h / Inert atmosphere
2: pyridine; 4-(N,N-dimethlyamino)pyridine / 0.25 h / 60 °C / Microwave irradiation; Inert atmosphere
3: toluene-4-sulfonic acid / para-xylene / 18 h / 140 °C / Inert atmosphere
4: 10 palladium on activated carbon; hydrogen / methanol; ethanol; ethyl acetate / 3 h / 20 °C
View Scheme
参考文献
Keurulainen, Leena; Salin, Olli; Siiskonen, Antti; Kern, Jan Marco; Alvesalo, Joni; Kiuru, Paula; Maass, Matthias; Yli-Kauhaluoma, Jari; Vuorela, Pia
Journal of Medicinal Chemistry, 2010 , vol. 53, # 21 p. 7664 - 7674
反应条件
1: pyridine; 4-(N,N-dimethlyamino)pyridine / 0.25 h / 60 °C / Microwave irradiation; Inert atmosphere
2: toluene-4-sulfonic acid / para-xylene / 18 h / 140 °C / Inert atmosphere
3: 10 palladium on activated carbon; hydrogen / methanol; ethanol; ethyl acetate / 3 h / 20 °C
View Scheme
参考文献
Keurulainen, Leena; Salin, Olli; Siiskonen, Antti; Kern, Jan Marco; Alvesalo, Joni; Kiuru, Paula; Maass, Matthias; Yli-Kauhaluoma, Jari; Vuorela, Pia
Journal of Medicinal Chemistry, 2010 , vol. 53, # 21 p. 7664 - 7674
