4-氯-5-氟-2-硝基苯胺合成路线 （共 3 条）
反应条件
1: With potassium nitrate; trifluoroacetic anhydride
T=20°C; 12 h;
2: With potassium carbonate
T=20°C; 0.5 h;
参考文献
Okamoto, Osamu; Kobayashi, Kensuke; Kawamoto, Hiroshi; Ito, Satoru; Yoshizumi, Takashi; Yamamoto, Izumi; Hashimoto, Masaya; Shimizu, Atsushi; Takahashi, Hiroyuki; Ishii, Yasuyuki; Ozaki, Satoshi; Ohta, Hisashi
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3282 - 3285
反应条件
sulfuric acid
T=100°C; 0.25 h;
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
1: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min
2: conc. sulfuric acid / 0.25 h / 100 °C
View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
