5-羟基甲基-3-(4-甲氧基苯基l)-2-噁唑烷酮合成路线 （共 6 条）
反应条件
carbon tetrabromide; triphenylphosphine in acetonitrile 24 h; Ambient temperature;
参考文献
Gates, Kent S.; Silverman, Richard B.
Journal of the American Chemical Society, 1989 , vol. 111, # 24 p. 8891 - 8895
反应条件
sodium methylate in methanol; toluene
T=105°C; 3 h;
参考文献
Gates, Kent S.; Silverman, Richard B.
Journal of the American Chemical Society, 1990 , vol. 112, # 25 p. 9364 - 9372
反应条件
1: 31 percent / methanol / 1.) 50 deg C, 12 h, 2.) reflux, 12 h
2: 83 percent / sodium methoxide / toluene; methanol / 3 h / 105 °C
View Scheme
参考文献
Gates, Kent S.; Silverman, Richard B.
Journal of the American Chemical Society, 1990 , vol. 112, # 25 p. 9364 - 9372
参考文献
Ding; Silverman
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3606 - 3610
反应条件
1: triphenylphosphine, carbon tetrachloride / acetonitrile / 24 h / Ambient temperature
2: tributylstannane, azobisisobutyronitrile / 7 h / 190 °C
View Scheme
参考文献
Gates, Kent S.; Silverman, Richard B.
Journal of the American Chemical Society, 1989 , vol. 111, # 24 p. 8891 - 8895
反应条件
(i) PhNEt2, toluene, (ii) NH3, benzene; Multistep reaction;
参考文献
Fauran; Douzon
1973 , vol. 8, # 3 p. 324 - 327
