2-(4-硝基苯基)-1,3,4-噁二唑合成路线 （共 10 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=760.051 Torr;
参考文献
AGIOS PHARMACEUTICALS, INC.; POPOVICI-MULLER, Janeta; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.; TRAVINS, Jeremey; YAN, Shunqi
Patent: WO2012/9678 A1, 2012 ;
Location in patent: Page/Page column 221 ;
WO 2012/009678 A1
反应条件
hydrogen; palladium on activated charcoal in methanol P=760 Torr; 1 h; Ambient temperature;
参考文献
Vincent,M.
Bulletin de la Societe Chimique de France, 1962 , p. 1587 - 1591
参考文献
AGIOS PHARMACEUTICALS, INC.; POPOVICI-MULLER, Janeta; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.; TRAVINS, Jeremey; YAN, Shunqi
Patent: WO2012/9678 A1, 2012 ;
Location in patent: Page/Page column 220-221 ;
WO 2012/009678 A1
反应条件
dicyclohexyl-carbodiimide in toluene
T=120°C; 0.25 h;
参考文献
Povazanec, Frantisek; Kovac, Jaroslav; Svoboda, Jozef
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 4 p. 1299 - 1300
反应条件
1: methyl (4-nitrophenyl)carboxylate With hydrazine hydrate
T=20°C;
2: trimethyl orthoformate 10 h; Heating;
参考文献
Nowak-Wydra, Barbara; Gierczyk, Blazej; Schroeder, Grzegorz
Magnetic Resonance in Chemistry, 2003 , vol. 41, # 9 p. 689 - 692
参考文献
Eilingsfeld,H. et al.
Chemische Berichte, 1963 , vol. 96, p. 2671 - 2690
反应条件
1: hydrazine
2: Heating
View Scheme
参考文献
Gierczyk, Blazej; Zalas, MacIej; Kazmierczak, Marcin; Grajewski, Jakub; Pankiewicz, Radoslaw; Wyrzykiewicz, Bozena
Magnetic Resonance in Chemistry, 2011 , vol. 49, # 10 p. 648 - 654
反应条件
1: sulfuric acid / Reflux
2: hydrazine hydrate; methanol / 20 °C
3: Reflux
View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; POPOVICI-MULLER, Janeta; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.; TRAVINS, Jeremey; YAN, Shunqi
Patent: WO2012/9678 A1, 2012 ;
WO 2012/009678 A1
反应条件
(i) Ac2O, HClO4, (ii) Na2CO3, H2O; Multistep reaction;
参考文献
Boyd,G.V.; Dando,S.R.
Journal of the Chemical Society [Section] C: Organic, 1970 , p. 1397 - 1401
反应条件
1: H2 / Pd-C / methanol / 1 h / 760 Torr / Ambient temperature
2: Py / 4 h / 95 °C
3: aq. NaOH / Heating
View Scheme
参考文献
Vincent,M.
Bulletin de la Societe Chimique de France, 1962 , p. 1587 - 1591
