反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C to -55 deg C, 30 min; 2.) THF, hexane, -78 deg C to r.t., overnight
2: 1.) n-BuLi; 3.) K2CO3 / 1.) THF, hexane, -78 deg C then -55 deg C, 15 min; 2.) THF, hexane, -78 deg C then to r.t., 15 min; 3.) CH3CN, reflux, 30 min
3: 65 percent / t-BuOK / tetrahydrofuran / 1 h / 0 °C
View Scheme
参考文献
Hendrickson, James B.; Boudreaux, Gerald J.; Palumbo, Paul S.
Journal of the American Chemical Society, 1986 , vol. 108, # 9 p. 2358 - 2366
