(S)-2-(苄氧羰基氨基)丁酸合成路线 （共 10 条）
反应条件
sodium hydrogencarbonate in water 20 h; Ambient temperature;
参考文献
Itaya; Shimizu; Nakagawa; Morisue
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 9 p. 1927 - 1930
反应条件
potassium carbonate in water
参考文献
KYORIN PHARMACEUTICAL CO., LTD.
Patent: EP443498 A1, 1991 ;
反应条件
1.) CuCN 1.) ether, THF, - 23 deg C, 20 min, 2.) THF, -23 deg C, 20 min; Yield given. Multistep reaction;
参考文献
Arnold, Lee D.; Drover, John C. G.; Vederas, John C.
Journal of the American Chemical Society, 1987 , vol. 109, # 15 p. 4649 - 4659
反应条件
sodium hydroxide; benzyl chloroformate
参考文献
Izumiya et al.
Nippon Kagaku Zasshi, 1958 , vol. 79, p. 420,423
Chem.Abstr., 1960 , p. 4408
Full Text Show Details
Waley
Biochemical Journal, 1958 , vol. 68, p. 189,191
反应条件
1: 4-dimethylaminopyridine, EDC*HCl / CH2Cl2 2: Aspergillus niger lipase, poly(vinyl alcohol), Phosphate buffer (pH 7.0), NaOH / 49 h / 25 °C View Scheme
参考文献
Miyazawa, Toshifumi; Takitani, Tadanori; Ueji, Shinichi; Yamada, Takashi; Kuwata, Shigeru
Journal of the Chemical Society, Chemical Communications, 1988 , # 17 p. 1214 - 1216
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Johnston, Meghan; Bhatt, Shachi R.; Sikka, Surina; Mercier, Richard W.; West, Jay M.; Makriyannis, Alexandros; Gatley, S. John; Duclos Jr., Richard I.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4585 - 4592
反应条件
hydrogenchloride; bis(1,5-cyclooctadiene)nickel (0); N,N,N',N,-tetramethylethylenediamine 1.) THF, reflux, 2.5h. (or tricyclohexylphosphine instead of N,N,N',N'-tetramethylethylenediamine); Yield given. Multistep reaction;
参考文献
Castano; Echavarren
Tetrahedron Letters, 1990 , vol. 31, # 33 p. 4783 - 4786
反应条件
hydrogenchloride; bis(1,5-cyclooctadiene)nickel (0); 2,9-dimethyl-1,10-phenanthroline 1.) THF, reflux, 2.5h.; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Castano; Echavarren
Tetrahedron Letters, 1990 , vol. 31, # 33 p. 4783 - 4786
反应条件
hydrogenchloride; sodium borohydride; acetic anhydride; toluene-4-sulfonic acid in tetrahydrofuran; water; benzene
参考文献
KYORIN PHARMACEUTICAL CO., LTD.
Patent: EP443498 A1, 1991 ;
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran
T=0°C; 3.5 h;
参考文献
Sun, Zhong-Yue; Kwon, Chul-Hoon; Wurpel, John N. D.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2841 - 2845
