6-甲氧基-1,2,3,4-四氢异喹啉合成路线 （共 38 条）
反应条件
1: hydrogenchloride / isopropyl alcohol; water / 18 h / 20 °C 2: sodium hydrogencarbonate / water / 0.5 h / 20 °C View Scheme
参考文献
Yang, Su Hui; Song, Chin-Hee; Van, Hue Thi My; Park, Eunsook; Khadka, Daulat Bikram; Gong, Eun-Yeung; Lee, Keesook; Cho, Won-Jea
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3414 - 3418
反应条件
1: polyphosphoric acid / 0.08 h / 145 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / |Reflux View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana
Patent: WO2013/80222 A1, 2013 ;
反应条件
1: concentrated ammonia 2: alkaline potassium hypobromite / 60 °C 3: und Abdampfen des Reaktionsprodukts mit 20percentiger Salzsaeure auf dem Wasserbad View Scheme
参考文献
Helfer
Helvetica Chimica Acta, 1924 , vol. 7, p. 955
反应条件
1: alkaline potassium hypobromite / 60 °C 2: und Abdampfen des Reaktionsprodukts mit 20percentiger Salzsaeure auf dem Wasserbad View Scheme
参考文献
Helfer
Helvetica Chimica Acta, 1924 , vol. 7, p. 955
反应条件
trifluoroacetic acid 15 h; Heating; Title compound not separated from byproducts.;
参考文献
Dalence-Guzman, Maria F.; Berglund, Magnus; Skogvall, Staffan; Sterner, Olov
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2499 - 2512
反应条件
1: 2 percent Chromat. / POCl3 2: 58 percent / aq. HCl View Scheme
参考文献
Euerby, Melvin R.; Waigh, Roger D.
Journal of Chemical Research, Miniprint, 1987 , # 2 p. 501 - 526
反应条件
ueber mehrere Stufen;
参考文献
Helfer
Helvetica Chimica Acta, 1924 , vol. 7, p. 955
反应条件
(Ru2(η5-C5Ph4O)2(H)2(CO)4) in 1,3,5-trimethyl-benzene T=165°C; 24 h; Inert atmosphere;
参考文献
Muthaiah, Senthilkumar; Hong, Soon Hyeok
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 16 p. 3045 - 3053
参考文献
Helvetica Chimica Acta, , vol. 7, p. 955
反应条件
hydrogenchloride in water; ethyl acetate T=100°C; Pictet-Spengler reaction; 1 h;
参考文献
LABORATORIOS DEL DR. ESTEVE, S.A.
Patent: EP1676844 A1, 2006 ;
Location in patent: Page/Page column 13 ;
