7-硝基-1,2,3,4-四氢异喹啉合成路线 （共 24 条）
反应条件
P2O5/silica gel; nitric acid in water T=20°C; 0.333333 h;
参考文献
Hajipour, Abdol R.; Guo, Lian-Wang; Pal, Arindam; Mavlyutov, Timur; Ruoho, Arnold E.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7435 - 7440
反应条件
lithium hydroxide in tetrahydrofuran; methanol 1 h;
参考文献
Hutchinson, John H.; Cook, Jacquelynn J.; Brashear, Karen M.; Breslin, Michael J.; Glass, Joan D.; Gould, Robert J.; Halczenko, Wasyl; Holahan, Marie A.; Lynch, Robert J.; Sitko, Gary R.; Stranieri, Maria T.; Hartman, George D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 23 p. 4583 - 4591
反应条件
1: With sulfuric acid; potassium nitrate T=0 - 20°C; 3 h; 2: With ammonia in water T=0°C; pH=10;
参考文献
CELLZOME AG
Patent: WO2009/62658 A1, 2009 ;
Location in patent: Page/Page column 36 ;
WO 2009/062658 A1
参考文献
SmithKline Beecham Corporation
Patent: US6117866 A1, 2000 ;
反应条件
1: 86 percent / conc. H2SO4 / acetic acid / 20 h / 25 °C 2: 11 g / K2CO3 / methanol; H2O / 18 h View Scheme
参考文献
Hutchinson, John H.; Cook, Jacquelynn J.; Brashear, Karen M.; Breslin, Michael J.; Glass, Joan D.; Gould, Robert J.; Halczenko, Wasyl; Holahan, Marie A.; Lynch, Robert J.; Sitko, Gary R.; Stranieri, Maria T.; Hartman, George D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 23 p. 4583 - 4591
反应条件
1: aqueous nitric acid; sulfuric acid 2: hydrogen chloride; ethanol View Scheme
参考文献
Ochiai; Nakagome
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 497,500
反应条件
hydrogenchloride; ethanol
参考文献
Ochiai; Nakagome
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 497,500
反应条件
1: sodium acetate 2: hydrogen chloride; ethanol View Scheme
参考文献
Ochiai; Nakagome
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 497,500
反应条件
1: formic acid With acetic anhydride T=0 - 50°C; 0.75 h; 2: 7-nitro-1,2,3,4-tetrahydro-isoquinoline in tetrahydrofuran T=-18 - -15°C; 0.5 h; 3: With hydrogenchloride; BH3.DMS more than 3 stages;
参考文献
AUCKLAND UNISERVICES LIMITED
Patent: WO2006/104406 A1, 2006 ;
Location in patent: Page/Page column 157-158 ;
反应条件
in acetic acid T=100°C; 4 h;
参考文献
GLAXOSMITHKLINE LLC; KALLANDER, Lara, S.; LAWHORN, Brian, Griffin; PHILIP, Joanne; ZHAO, Yongdong
Patent: WO2011/88027 A1, 2011 ;
Location in patent: Page/Page column 78 ;
