2-氨基-4-甲氧基苯甲酸合成路线 （共 38 条）
反应条件
ueber die Diazonium-Verbindung dargestellt;
参考文献
Scherlin et al.
Zhurnal Obshchei Khimii, 1938 , vol. 8, p. 884,887
Chem. Zentralbl., 1939 , vol. 110, # I p. 4324
反应条件
1: borane-THF / tetrahydrofuran / 0 - 20 °C
2: manganese(IV) oxide / dichloromethane / 20 °C
3: N-bromosuccinmide / dichloromethane
4: neat (no solvent) / 2 h / 180 °C
5: trichlorophosphate / 5 h / 130 °C
View Scheme
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
反应条件
1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / |Inert atmosphere
2: manganese(IV) oxide / dichloromethane / 23 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
反应条件
1: (i) NaNO2, aq. HCl, (ii) aq. KI, H2SO4
2: Cu, aq. KOH / Heating
View Scheme
参考文献
Sindelar; Jilek; Metysova; et al.
Collection of Czechoslovak Chemical Communications, 1974 , vol. 39, # 12 p. 3548 - 3559
反应条件
(i) aq. H2SO4, NaNO2, (ii) KI; Multistep reaction;
参考文献
Cell Pathways, Inc.
Patent: US5942520 A1, 1999 ;
反应条件
hydrogenchloride; potassium iodide; sodium nitrite in water; toluene
参考文献
Sterling Winthrop Inc.
Patent: US5614530 A1, 1997 ;
反应条件
1: (i) NaNO2, aq. HCl, (ii) aq. KI, H2SO4
2: Cu, aq. KOH / Heating
3: Na<AlH2(OCH2CH2OMe)2> / benzene
View Scheme
参考文献
Sindelar; Jilek; Metysova; et al.
Collection of Czechoslovak Chemical Communications, 1974 , vol. 39, # 12 p. 3548 - 3559
反应条件
1: (i) NaNO2, aq. HCl, (ii) aq. KI, H2SO4
2: Cu, aq. KOH / Heating
3: Na<AlH2(OCH2CH2OMe)2> / benzene
4: SOCl2, Py / CHCl3
View Scheme
参考文献
Sindelar; Jilek; Metysova; et al.
Collection of Czechoslovak Chemical Communications, 1974 , vol. 39, # 12 p. 3548 - 3559
