1-(5-甲基吡啶-3-基)乙酮合成路线 （共 6 条）
反应条件
sodium hydroxide; bromine in water Ambient temperature;
参考文献
Freyne, Eddy J.; Esmans, Eddy L.; Lepoivre, Josef A.; Alderweireldt, Frank C.
Carbohydrate Research, 1980 , vol. 78, p. 235 - 242
反应条件
1: 61 percent / bromine/sodium hydroxide / H2O / Ambient temperature 2: 63 percent / diethyl ether; methanol View Scheme
参考文献
Freyne, Eddy J.; Esmans, Eddy L.; Lepoivre, Josef A.; Alderweireldt, Frank C.
Carbohydrate Research, 1980 , vol. 78, p. 235 - 242
反应条件
in diethyl ether
T=0 - 20°C; 6 h;
参考文献
ALMIRALL PRODESFARMA, S.A.
Patent: WO2005/49581 A1, 2005 ;
Location in patent: Page/Page column 80 ;
WO 2005/049581 A1
反应条件
bis-triphenylphosphine-palladium(II) chloride; tributyl(ethoxyvinyl)-tin; potassium carbonate in water; N,N-dimethyl-formamide
T=110°C; 1 h; Microwave irradiation;
参考文献
SANOFI; EL-AHMAD, Youssef; FILOCHE-ROMME, Bruno; GANZHORM, Axel; MARCINIAK, Gilbert; MUZET, Nicolas; RONAN, Baptiste; VIVET, Bertrand; ZERR, Véronique
Patent: WO2013/190123 A1, 2013 ;
Location in patent: Page/Page column 46 ;
反应条件
1: 5-bromo-3-methylpyridine With n-butyllithium in diethyl ether
T=-78°C; 0.5 h;
2: N,O-dimethylacetohydroxamic acid in diethyl ether
T=-78 - 20°C; Claisen Condensation;
参考文献
MERCK SHARP and DOHME CORP.; LI, Dansu; ROECKER, Anthony, J.
Patent: WO2013/62858 A1, 2013 ;
Location in patent: Page/Page column 38 ;
反应条件
in tetrahydrofuran; diethyl ether
2 h; Heating / reflux;
参考文献
IRM LLC; NOVARTIS AG; LI, Xiaolin; LIU, Xiaodong; MOLTENI, Valentina; CHIANELLI, Donatella; LOREN, Jon; NABAKKA, Juliet
Patent: WO2008/137794 A1, 2008 ;
Location in patent: Page/Page column 31-32 ;
WO 2008/137794 A1
