反-3-羟基-L-脯氨酸合成路线 （共 23 条）
反应条件
1: 79 percent / aluminum amalgam, NaHCO3 (half sat.) / ethanol; acetone / 2 h 2: 74 percent / imidazole / dimethylformamide / 6 h / 40 °C 3: 1.) BH3*SMe, 2.) TMEDA / 1.) THF, 70 deg C, 2 h, 2.) THF, Et2O, RT, 6 h 4: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr 5: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature 6: 70 percent / 6 M aq. HCl / 3 h / Heating View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 5, # 1 p. 119 - 128
反应条件
1: 70 percent / 1.) Pd(dba)2, Dppb, mercaptobenzoic acid, 2.) 1M HCl / tetrahydrofuran / Ambient temperature 2: 88 percent / KOH / methanol; H2O / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 32 p. 5743 - 5746
反应条件
1: HCl / methanol / -20 °C 2: Amberlyst 15 / 65 °C 3: 70 percent / 1.) Pd(dba)2, Dppb, mercaptobenzoic acid, 2.) 1M HCl / tetrahydrofuran / Ambient temperature 4: 88 percent / KOH / methanol; H2O / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 32 p. 5743 - 5746
反应条件
1: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature 2: 70 percent / 6 M aq. HCl / 3 h / Heating View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 5, # 1 p. 119 - 128
反应条件
1: 80 percent / aq. NaOH / tetrahydrofuran 2: diethyl ether 3: PPh3P; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h 4: aq. NaOH / tetrahydrofuran / 1 h View Scheme
参考文献
Hodges, Jonathan A.; Raines, Ronald T.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15923 - 15932
反应条件
1: 99 percent / HCl / 0 - 20 °C 2: 80 percent / Et3N / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Gomez-Vidal, Jose A.; Silverman, Richard B.
Organic Letters, 2001 , vol. 3, # 16 p. 2481 - 2484
反应条件
sodium hydrogencarbonate in 1,4-dioxane T=0 - 20°C; 9 h;
参考文献
Mayer, Alain; Leumann, Christian J.
European Journal of Organic Chemistry, 2007 , # 24 p. 4038 - 4049
反应条件
1.1: 80 percent / aq. NaOH / tetrahydrofuran 2.1: diethyl ether 3.1: PPh3P; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h 4.1: aq. NaOH / tetrahydrofuran / 1 h 5.1: Cs2CO3 / dimethylformamide / 0 °C 5.2: 5.3 g / dimethylformamide / 20 °C 6.1: morph-DAST / tetrahydrofuran / -78 - 20 °C 7.1: H2 / Pd/C / methanol 8.1: HCl / dioxane / 1.5 h View Scheme
参考文献
Hodges, Jonathan A.; Raines, Ronald T.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15923 - 15932
反应条件
sodium hydroxide in tetrahydrofuran T=20°C;
参考文献
Napolitano, Carmela; Borriello, Manuela; Cardullo, Francesca; Donati, Daniele; Paio, Alfredo; Manfredini, Stefano
Tetrahedron Letters, 2009 , vol. 50, # 52 p. 7280 - 7282
反应条件
triethylamine in 1,4-dioxane; methanol; water T=20°C; 4 h;
参考文献
Gomez-Vidal, Jose A.; Silverman, Richard B.
Organic Letters, 2001 , vol. 3, # 16 p. 2481 - 2484
