1: 3-(trifluoromethyl)phenylsulfonyl chloride With sodium hydrogencarbonate; sodium sulfite in water T=75°C; 1 h; 2: 1-bromopropanecarboxylic acid With sodium hydroxide in water 30 h; Reflux;

copper(l) iodide; sodium (SC)-prolinate in dimethyl sulfoxide T=80°C; 24 h;

1: 1-bromo-3-trifluoromethyl-benzene With 1,10-phenanthroline; K2S2O5; tetrabutylammomium bromide; sodium formate; palladium diacetate; triphenylphosphine in dimethyl sulfoxide T=70°C; 20 h; Inert atmosphereMicrowave irradiation; 2: methyl iodide in dimethyl sulfoxide T=23°C; 20 h; Inert atmosphere; chemoselective reaction;

anhydrous potassium sulfate; potassium hydrogensulfate; oxone in water; acetone cooling;

trifluorormethanesulfonic acid; Boron tris(trifluoromethanesulfonate) T=20°C; Substitution; 3 h;