4-(6-甲氧基-1,3-苯并噻唑-2-基)苯胺合成路线 （共 14 条）
反应条件
potassium carbonate in dimethyl sulfoxide T=100°C; 16 h;
参考文献
UNIVERSITY OF PITTSBURGH
Patent: US2003/236391 A1, 2003 ;
Location in patent: Page 15 - 16 ;
反应条件
potassium carbonate in dimethyl sulfoxide
参考文献
Klunk, William E.; Mathis JR., Chester A.; Wang, Yanming
Patent: US2002/133019 A1, 2002 ;
反应条件
potassium carbonate in dimethyl sulfoxide T=140°C; 16 h;
参考文献
Mathis, Chester A; Wang, Yanming; Holt, Daniel P; Huang, Guo-Feng; Debnath, Manik L; Klunk, William E
Journal of medicinal chemistry, 2003 , vol. 46, # 13 p. 2740 - 2754
反应条件
caesium carbonate; copper(I) bromide; Pd(OAc)2*P(t-Bu)3 in N,N-dimethyl-formamide
T=150°C; 3 h;
参考文献
Alagille, David; Baldwin, Ronald M.; Tamagnan, Gilles D.
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1349 - 1351
反应条件
1: With potassium carbonate in water; N,N-dimethyl-formamide
Suzuki-Miyaura Coupling; 1 h; Inert atmosphere;
2: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in water; N,N-dimethyl-formamide
T=80°C; Suzuki-Miyaura Coupling; 3 h; Inert atmosphere; TemperatureTime;
参考文献
Bort, Guillaume; Sylla-Iyarreta Veitia, Maite; Ferroud, Clotilde
Tetrahedron, 2013 , vol. 69, # 35 p. 7345 - 7353
反应条件
caesium carbonate; copper(I) bromide; Pd(OAc)2*P(t-Bu)3 in N,N-dimethyl-formamide
T=150°C; 1 h;
参考文献
Alagille, David; Baldwin, Ronald M.; Tamagnan, Gilles D.
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1349 - 1351
反应条件
1: 64 percent / Lawesson's reagent / chlorobenzene / 3 h / Heating
2: aq. NaOH; K3Fe(CN)6 / ethanol / 0.5 h / Heating
3: 97 percent / SnCl2; ethanol / 4 h / Heating
View Scheme
参考文献
Mathis, Chester A; Wang, Yanming; Holt, Daniel P; Huang, Guo-Feng; Debnath, Manik L; Klunk, William E
Journal of medicinal chemistry, 2003 , vol. 46, # 13 p. 2740 - 2754
反应条件
1: pyridine / 2 h / 100 °C
2: Lawesson's reagent / chlorobenzene / 6 h / Reflux
3: sodium hydroxide; K3Fe(CN)6 / ethanol; water / 1 h / 90 °C
4: tin(ll) chloride / ethanol / 4 h / Reflux; Inert atmosphere
View Scheme
参考文献
Chi, Dae-Yoon; Lee, Byoung-Se; Uthaiwan, Sirion; Chu, So-Young; Bae, Yu-Jin; Park, Chansoo; Moon, Dae-Hyuk; Ryu, Jin-Sook; Kim, Jae-Seung; Oh, Seung-Jun
Patent: US2012/214994 A1, 2012 ;
反应条件
in ethanol; ethyl acetate
参考文献
Klunk, William E.; Mathis JR., Chester A.; Wang, Yanming
Patent: US2002/133019 A1, 2002 ;
反应条件
1: pyridine / 2 h / 100 °C
2: Lawesson's reagent / chlorobenzene / 6 h / Reflux
3: sodium hydroxide; K3Fe(CN)6 / ethanol; water / 1 h / 90 °C
4: tin(ll) chloride / ethanol / 4 h / Reflux; Inert atmosphere
View Scheme
参考文献
Chi, Dae-Yoon; Lee, Byoung-Se; Uthaiwan, Sirion; Chu, So-Young; Bae, Yu-Jin; Park, Chansoo; Moon, Dae-Hyuk; Ryu, Jin-Sook; Kim, Jae-Seung; Oh, Seung-Jun
Patent: US2012/214994 A1, 2012 ;
