4'-叔-丁基-4-[4-(羟基二苯甲基)哌啶]苯丁酮合成路线 （共 8 条）
反应条件
sodium tetrahydroborate in methanol
参考文献
Zhang; Ter Laak; Timmerman
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 165 - 173
反应条件
Streptomyces platensis NRRL 2364 in N,N-dimethyl-formamide T=30°C; pH=5; 35 h; aq. bufferMicrobiological reaction;
参考文献
El Ouarradi, Amane; Salard-Arnaud, Isabelle; Buisson, Didier
Tetrahedron, 2008 , vol. 64, # 51 p. 11738 - 11744
反应条件
18-crown-6 ether; potassium carbonate; potassium iodide in acetonitrile
T=175°C; P=4875.49 Torr; 0.75 h; microwave irradiation;
参考文献
Holzer, Marcel; Ziegler, Sigrid; Albrecht, Beatrice; Kronenberger, Bernd; Kaul, Artur; Bartenschlager, Ralf; Kattner, Lars; Klein, Christian D.; Hartmann, Rolf W.
Molecules, 2008 , vol. 13, # 5 p. 1081 - 1110
反应条件
potassium carbonate in butanone
Heating;
参考文献
Zhang; Ter Laak; Timmerman
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 165 - 173
反应条件
sodium carbonate; sodium iodide in N,N-dimethyl-formamide
24 h; Reflux;
参考文献
El Ouarradi, Amane; Salard-Arnaud, Isabelle; Buisson, Didier
Tetrahedron, 2008 , vol. 64, # 51 p. 11738 - 11744
反应条件
1: NaI / acetone / 6 h / Heating
2: 75 percent / K2CO3 / butan-2-one / Heating
View Scheme
参考文献
Zhang; Ter Laak; Timmerman
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 165 - 173
反应条件
pyridinium chlorochromate
Oxidation;
参考文献
Yang; Prakash; Roden; Snyders
British Journal of Pharmacology, 1995 , vol. 115, # 2 p. 267 - 274
参考文献
Lafite, Pierre; Dijols, Sylvie; Buisson, Didier; Macherey, Anne-Christine; Zeldin, Darryl C.; Dansette, Patrick M.; Mansuy, Daniel
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 10 p. 2777 - 2780
