4'-叔丁基-4-氯丁酰苯合成路线 （共 12 条）
反应条件
1: γ-chlorobutyryl chloride With 1-methyl-pyrrolidin-2-one in toluene T=0°C; 0.5 h; 2: 4-tert-Butylphenylmagnesium bromide in tetrahydrofuran; toluene T=-10 - 0°C; 4.25 h; chemoselective reaction;
参考文献
Gowda, Maravanhalli Sidde; Pande, Sushanth Sudhir; Ramakrishna, Ramesha Andagar; Prabhu, Kandikere Ramaiah
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 15 p. 5365 - 5368
参考文献
Gronnier, Colombe; Kramer, Soren; Odabachian, Yann; Gagosz, Fabien
Journal of the American Chemical Society, 2012 , vol. 134, # 2 p. 828 - 831
参考文献
Ube Industries, Ltd.
Patent: US4929618 A1, 1990 ;
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=25°C; 1 h;
参考文献
Lebel, Helene; Davi, Michael; Diez-Gonzalez, Silvia; Nolan, Steven P.
Journal of Organic Chemistry, 2007 , vol. 72, # 1 p. 144 - 149
反应条件
1: NaI / acetone / 6 h / Heating 2: 75 percent / K2CO3 / butan-2-one / Heating 3: 96 percent / NaBH4 / methanol View Scheme
参考文献
Carr; Meyer
Arzneimittel-Forschung/Drug Research, 1982 , vol. 32, # 9 A p. 1157 - 1159
反应条件
potassium carbonate in isobutyl methylketone T=105 - 116°C; 2.25 h; Inert atmosphere;
参考文献
Arevipharma GmbH
Patent: EP2371817 A1, 2011 ;
Location in patent: Page/Page column 27 ;
反应条件
sodium hydrogencarbonate in isobutyl methylketone T=119°C; 11 h;
参考文献
AREVIPHARMA GMBH; SCHICKANEDER, Christian; MCGRATH, Matthew; SCHAeFER, Juergen; SCHUBERT, Jana; JACOB, Ulrike; MAeRTENS, Welljanne
Patent: WO2011/121099 A2, 2011 ;
Location in patent: Page/Page column 42 ;
反应条件
1: With sodium hydrogencarbonate in isobutyl methylketone T=119°C; 11 h; 2: With oxalic acid in isobutyl methylketone 3: With ammonia in water pH=7 - 7.5;
参考文献
Arevipharma GmbH
Patent: EP2371817 A1, 2011 ;
Location in patent: Page/Page column 29 ;
反应条件
sodium hydrogencarbonate in toluene 12 h; Reflux; Product distribution / selectivity;
参考文献
AREVIPHARMA GMBH; SCHICKANEDER, Christian; MCGRATH, Matthew; SCHAeFER, Juergen; SCHUBERT, Jana; JACOB, Ulrike; MAeRTENS, Welljanne
Patent: WO2011/121099 A2, 2011 ;
Location in patent: Page/Page column 40-41 ;
反应条件
1.1: sodium hydrogencarbonate / toluene / Reflux 2.1: toluene-4-sulfonic acid / toluene / 100 - 110 °C / Reflux 2.2: Reflux 3.1: sodium hydroxide / ethyl acetate; water / 0.5 h / 20 °C View Scheme
参考文献
MICRO LABS LIMITED; REDDY, Thirupalu, M.; N, Chittibabu; REDDY, Srinivasa, P.; REDDY, Phanikumar, B.; CHELUVARAJU; RAO, Madhusudana, G.; SURVE, Pradeep, G.; MANDPE, Pankaj, S.
Patent: WO2012/76919 A1, 2012 ;
