2-氨基-4-甲基-噻吩-3-羧酸乙酯合成路线 （共 5 条）
反应条件
morpholine; sulfur in ethanol T=90°C; Gewald reaction;
参考文献
Nakhi, Ali; Adepu, Raju; Rambabu; Kishore, Ravada; Vanaja; Kalle, Arunasree M.; Pal, Manojit
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 13 p. 4418 - 4427
反应条件
in ethanol Inert atmosphere;
参考文献
Nimbus Apollo, Inc.; Harriman, Geraldine C.; Masse, Craig E.; Harwood, James; Bhat, Sathesh; Greenwood, Jeremy Robert
Patent: US2013/123231 A1, 2013 ;
Location in patent: Paragraph 1423; 1426; 1427 ;
反应条件
1: 74 percent / S8; morpholine / ethanol / 5 h / 60 °C 2: 85 percent / 1M aq. HCl / ethanol / 1 h / Heating View Scheme
参考文献
Guetschow, Michael; Kuerschner, Lars; Neumann, Ulf; Pietsch, Markus; Loeser, Reik; Koglin, Norman; Eger, Kurt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5437 - 5447
反应条件
T=190°C; 2.5 h; Inert atmosphere;
参考文献
Lou, Jiangping; Liu, Zhen; Li, Yan; Zhou, Mi; Zhang, Zhengxi; Zheng, Shu; Wang, Renxiao; Li, Jian
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 22 p. 6662 - 6666
反应条件
in propan-1-ol
Heating;
参考文献
Sauter,F.; Deinhammer,W.
Monatshefte fuer Chemie, 1973 , vol. 104, p. 1593 - 1598
