5-甲基-噻吩并[2,3-d]嘧啶-4(1H)-酮合成路线 （共 9 条）
反应条件
T=190°C; 2.5 h; Inert atmosphere;
参考文献
Lou, Jiangping; Liu, Zhen; Li, Yan; Zhou, Mi; Zhang, Zhengxi; Zheng, Shu; Wang, Renxiao; Li, Jian
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 22 p. 6662 - 6666
反应条件
1: 82 percent / sodium hydroxide / H2O / 1.5 h / Heating 2: 0.25 h / 350 °C View Scheme
参考文献
Grinev, A. N.; Kaplina, N. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 7 p. 767 - 770
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , # 7 p. 925 - 928
参考文献
Ashok; Satish Goud; Shravani; Rajaiah; Sarasija; Bhaskar
Indian Journal of Heterocyclic Chemistry, 2010 , vol. 20, # 2 p. 101 - 104
参考文献
Grinev, A. N.; Kaplina, N. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 7 p. 767 - 770
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , # 7 p. 925 - 928
反应条件
trichlorophosphate T=110°C; 1 h;
参考文献
JE IL PHARMACEUTICAL CO., LTD.
Patent: WO2007/102679 A1, 2007 ;
Location in patent: Page/Page column 49 ;
WO 2007/102679 A1
反应条件
pyridine; phosphorus oxytribromide
参考文献
Robba,M. et al.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968 , vol. 266, p. 1706 - 1708
反应条件
1: (chlorination) 2: N2H4 View Scheme
参考文献
Robba,M. et al.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968 , vol. 266, p. 1706 - 1708
反应条件
1: 4 h / Heating
2: mercuric bromide, mercuric oxide / benzene / 20 h / Heating
3: NH3 / methanol / 20 h / Ambient temperature
View Scheme
参考文献
Patil, Vemanna D.; Wise, Dean S.; Wotring, Linda L.; Bloomer, Linda C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 423 - 427
反应条件
1: N-chloro-succinimide; acetic acid / 1.5 h / 95 °C
2: thionyl chloride / N,N-dimethyl-formamide / 2 h / Reflux
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HECKEL, Armin; HIMMELSBACH, Frank; LEHMANN-LINTZ, Thorsten; REDEMANN, Norbert; SAUER, Achim; THOMAS, Leo; BLACK, Phillip; BLACKABY, Wesley; DANILEWICZ, John; LINNEY, Ian; AUSTEN, Matthias; SCHNEIDER, Martin; SCHREITER, Kay
Patent: WO2011/104338 A1, 2011 ;
WO 2011/104338 A1
