4-氯-5-甲基噻吩并[2,3-d]嘧啶合成路线 （共 4 条）
反应条件
trichlorophosphate T=110°C; 1 h;
参考文献
JE IL PHARMACEUTICAL CO., LTD.
Patent: WO2007/102679 A1, 2007 ;
Location in patent: Page/Page column 49 ;
WO 2007/102679 A1
参考文献
Robba,M. et al.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968 , vol. 266, p. 1706 - 1708
反应条件
1: in isopropyl alcohol
T=105°C; 2 h; Pressure tube;
2: With sodium hydroxide in water
参考文献
DEVELOGEN AKTIENGESELLSCHAFT
Patent: WO2007/59905 A2, 2007 ;
Location in patent: Page/Page column 49 ;
WO 2007/059905 A2
反应条件
toluene-4-sulfonic acid in isopropyl alcohol
T=100°C; 20 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HECKEL, Armin; HIMMELSBACH, Frank; LEHMANN-LINTZ, Thorsten; REDEMANN, Norbert; SAUER, Achim; THOMAS, Leo; BLACK, Phillip; BLACKABY, Wesley; DANILEWICZ, John; LINNEY, Ian; AUSTEN, Matthias; SCHNEIDER, Martin; SCHREITER, Kay
Patent: WO2011/104338 A1, 2011 ;
Location in patent: Page/Page column 64-65 ;
WO 2011/104338 A1
