1-(2-甲氧基苯基)-4-(2-氯乙基)哌嗪双盐酸盐合成路线 （共 7 条）
反应条件
sodium amide in toluene 24 h; Heating / reflux;
参考文献
EP1000046 B1, ;
Page/Page column 11 ;
EP 1000046 B1
反应条件
sodium hydroxide in acetone
T=20°C; 48 h;
参考文献
Mahesh; Venkatesha Perumal; Pandi
Pharmazie, 2005 , vol. 60, # 6 p. 411 - 414
反应条件
sodium hydroxide in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dimethyl sulfoxide
参考文献
Fick, David B.; Foreman, Mark M.; Glasky, Alvin J.; Helton, David R.
Patent: US2003/114463 A1, 2003 ;
US 20030114463 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether
T=40°C; 0.5 h;
参考文献
Colabufo, Nicola Antonio; Berardi, Francesco; Perrone, Roberto; Rapposelli, Simona; Digiacomo, Maria; Vanni, Michael; Balsamo, Aldo
Journal of Medicinal Chemistry, 2008 , vol. 51, # 23 p. 7602 - 7613
反应条件
triethylamine in acetonitrile
T=20°C; 40 h;
参考文献
Karramkam, Mylene; Hinnen, Francoise; Berrehouma, Myriam; Hlavacek, Christophe; Vaufrey, Francoise; Halldin, Christer; McCarron, Julie A.; Pike, Victor W.; Dolle, Frederic
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2769 - 2782
参考文献
Hoffmann-La Roche Inc.
Patent: US4202978 A1, 1980 ;
US 4202978 A
反应条件
in toluene
Alkylation; 6 h; Heating;
参考文献
Caliendo, Giuseppe; Fiorino, Ferdinando; Grieco, Paolo; Perissutti, Elisa; Santagada, Vincenzo; Severino, Beatrice; Bruni, Giancarlo; Romeo, Maria Rosaria
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 533 - 538
