3-溴-1,1,1-三氟丙酮合成路线 （共 31 条）
反应条件
in ethanol 0.5 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 23, # 4 p. 1031 - 1034
反应条件
in tetrachloromethane 24 h;
参考文献
Wheelock; Severson; Hammock
Chemical Research in Toxicology, 2001 , vol. 14, # 12 p. 1563 - 1572
反应条件
sodium hydroxide; sodium hydrogensulfide in diethyl ether; water T=0°C; 1 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2009/1214 A2, 2008 ;
Location in patent: Page/Page column 45 ;
WO 2009/001214 A2
反应条件
in ethanol T=20°C; 48 h; Reflux;
参考文献
ARES TRADING S.A.; JORAND-LEBRUN, Catherine; SWINNEN, Dominique; GERBER, Patrick; KULKARNI, Santosh
Patent: WO2012/130915 A1, 2012 ;
Location in patent: Page/Page column 74 ;
WO 2012/130915 A1
反应条件
1: 2-amino-pyrazine; 3-bromo-1,1,1-trifluoroacetone in ethanol 42 h; Heating / reflux; 2: sodium hydrogencarbonate in water pH=8;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/29051 A1, 2004 ;
Location in patent: Page 43-44 ;
WO 2004/029051 A1
反应条件
hydroxylamine hydrochloride in chloroform; water 24 h; Heating;
参考文献
Zimmer, Reinhold; Reissig, Hans-Ulrich
Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 339 - 347
反应条件
1: With bis[(1S,2R,3S,5S)-pinan-3-yl]chloroborane in diethyl ether T=-4 - 5°C; 72 h; 2: Further stages.;
参考文献
Durley; Grapperhaus; Massa; Mischke; Parnas; Fobian; Rath; Honda; Zeng; Connolly; Heuvelman; Witherbee; Glenn; Krul; Smith; Sikorski
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4575 - 4578
反应条件
sodium hydroxide; B-chloro-diisopinocampheylborane 1.) Et2O, -25 deg C, 96 h, 2.) 95-100 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ramachandran, P. Veeraraghavan; Gong, Baoqing; Brown, Herbert C.
Journal of Organic Chemistry, 1995 , vol. 60, # 1 p. 41 - 46
反应条件
sodium hydroxide; B-chloro-diisopinocampheylborane 1.) Et2O, -25 deg C, 96 h, 2.) 95-100 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ramachandran, P. Veeraraghavan; Gong, Baoqing; Brown, Herbert C.
Journal of Organic Chemistry, 1995 , vol. 60, # 1 p. 41 - 46
反应条件
sodium borohydride; dimethyl sulfoxide; palladium in ethanol; water
