1,1-二溴-3,3,3-三氟丙酮合成路线 （共 24 条）
反应条件
bromine in sulfuric acid 1) overnight, 2) brief reflux;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 27, # 1-12 p. 1051 - 1053
反应条件
phosphorus pentachloride in tetrachloromethane T=200°C; 72 h;
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 36, # 9 p. 1875 - 1880
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 9 p. 2024 - 2030
反应条件
1: 3,3-dibromo-1,1,1-trifluoropropanone With sodium acetate Hydrolysis; 0.5 h; Heating; 2: pyridine-4-carbaldehyde With ammonium hydroxide in methanol T=20°C; cyclocondensation; 20 h;
参考文献
Dhainaut, Alain; Tizot, Andre; Raimbaud, Eric; Lockhart, Brian; Lestage, Pierre; Goldstein, Solo
Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2165 - 2175
反应条件
1: 3,3-dibromo-1,1,1-trifluoropropanone With sodium acetate Hydrolysis; 0.5 h; Heating; 2: 4-chlorobenzaldehyde With ammonium hydroxide in methanol T=20°C; cyclocondensation; 20 h;
参考文献
Dhainaut, Alain; Tizot, Andre; Raimbaud, Eric; Lockhart, Brian; Lestage, Pierre; Goldstein, Solo
Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2165 - 2175
反应条件
1: 3,3-dibromo-1,1,1-trifluoropropanone With sodium acetate in water T=100°C; 0.5 h; 2: benzaldehyde With ammonia in methanol; water T=20°C; 28 h;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2008/171754 A1, 2008 ;
Location in patent: Page/Page column 93 ;
US 20080171754 A1
反应条件
ammonium hydroxide; sodium acetate in methanol; water 6 h; Ambient temperature;
参考文献
Moazzam, Muhammad; Parrick, J.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 1051 - 1053
反应条件
1: With sodium hydroxide T=0 - 20°C; 2: With sulfuric acid T=135°C; 8 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.
Patent: WO2011/53292 A1, 2011 ;
Location in patent: Page/Page column 132 ;
WO 2011/053292 A1
参考文献
Eli Lilly and Company
Patent: US4293552 A1, 1981 ;
反应条件
water; sodium acetate T=100°C; 0.666667 h;
参考文献
Novartis AG
Patent: US2007/49622 A1, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
1: 3,3-dibromo-1,1,1-trifluoropropanone With sodium acetate Hydrolysis; 0.5 h; Heating; 2: β-naphthaldehyde With ammonium hydroxide in methanol T=20°C; cyclocondensation; 20 h;
参考文献
Dhainaut, Alain; Tizot, Andre; Raimbaud, Eric; Lockhart, Brian; Lestage, Pierre; Goldstein, Solo
Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2165 - 2175
