反应条件
1: 3,3-dibromo-1,1,1-trifluoropropanone With sodium acetate in methanol; water T=98°C; 0.5 h; Inert atmosphere; 2: 4-bromo-1,2-phenylenediamine in methanol; water T=20°C; 17 h; Inert atmosphere; Overall yield = 65 percent; Overall yield = 4.2 g;
参考文献
Buerli, Roland W.; Luckhurst, Christopher A.; Aziz, Omar; Matthews, Kim L.; Yates, Dawn; Lyons, Kathy. A.; Beconi, Maria; McAllister, George; Breccia, Perla; Stott, Andrew J.; Penrose, Stephen D.; Wall, Michael; Lamers, Marieke; Leonard, Philip; Mueller, Ilka; Richardson, Christine M.; Jarvis, Rebecca; Stones, Liz; Hughes, Samantha; Wishart, Grant; Haughan, Alan F.; O'Connell, Catherine; Mead, Tania; McNeil, Hannah; Vann, Julie; Mangette, John; Maillard, Michel; Beaumont, Vahri; Munoz-Sanjuan, Ignacio; Dominguez, Celia
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9934 - 9954
