(R)-6-甲基四氢吡喃-2-酮合成路线 （共 34 条）
反应条件
4 A molecular sieve; H+ ion-exchange resin (Amberlyst 15) in acetonitrile
T=25°C; 4 h;
参考文献
Gerth, Dale B.; Giese, Bernd
Journal of Organic Chemistry, 1986 , vol. 51, # 19 p. 3726 - 3729
反应条件
hydrogen; palladium on activated charcoal in diethyl ether
P=760 Torr; 2 h;
参考文献
Procter, Garry; Russell, Andrew T.; Murphy, Patrick J.; Tan, T.S.; Mather, Andrew N.
Tetrahedron, 1988 , vol. 44, # 13 p. 3953 - 3974
反应条件
hydrogen; Ru2Cl4-(S)-(2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)2*NEt3 in dichloromethane
T=50°C; P=76000 Torr; Title compound not separated from byproducts;
参考文献
Ohta, Tetsuo; Miyake, Tsutomu; Seido, Nobuo; Kumobayashi, Hidenori; Takaya, Hidemasa
Journal of Organic Chemistry, 1995 , vol. 60, # 2 p. 357 - 363
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 24 h;
参考文献
Fazio, Fabio; Schneider, Manfred P.
Tetrahedron Letters, 2002 , vol. 43, # 5 p. 811 - 814
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
T=0°C; 24 h;
参考文献
Gadkari; Kapadi
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 5 p. 407 - 408
反应条件
in benzene
Yield given;
参考文献
Fukui, Hideto; Tsuchiya, Yoshinori; Fujita, Keiko; Nakagawa, Tadakiyo; Koshino, Hiroyuki; Nakata, Tadashi
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 16 p. 2081 - 2086
反应条件
1: 63 percent / hexane / 29 h / 30 °C / enzyme: Amano PS lipase
2: 5N NaOH / ethanol / 5 h / Heating
3: p-TsOH / toluene / Heating
View Scheme
参考文献
Sugai, Takeshi; Hamada, Keiji; Akeboshi, Tomohiro; Ikeda, Hajime; Ohta, Hiromichi
Synlett, 1997 , vol. 1997, # 8 p. 983 - 985
反应条件
toluene-4-sulfonic acid in toluene
1.3 h; Heating;
参考文献
Fazio, Fabio; Schneider, Manfred P.
Tetrahedron Letters, 2002 , vol. 43, # 5 p. 811 - 814
反应条件
Lactobacillus brevis alcohol dehydrogenase; isopropyl alcohol in aq. buffer
T=30°C; pH=9; 24 h; Enzymatic reaction;
参考文献
Diaz-Rodriguez, Alba; Borzeicka, Wioleta; Lavandera, Ivan; Gotor, Vicente
ACS Catalysis, 2014 , vol. 4, # 2 p. 386 - 393
反应条件
Lactobacillus brevis alcohol dehydrogenase; isopropyl alcohol in aq. buffer
T=30°C; pH=9; 24 h; Enzymatic reaction;
参考文献
Diaz-Rodriguez, Alba; Borzeicka, Wioleta; Lavandera, Ivan; Gotor, Vicente
ACS Catalysis, 2014 , vol. 4, # 2 p. 386 - 393
