(R)-6-甲基四氢吡喃-2-酮合成路线 （共 34 条）
反应条件
1: 95 percent / p-toluenesulfonic acid / CH2Cl2 / 1 h / 25 °C
2: 78 percent / NaI, azoisobutyronitrile, Bu3SnH / bis-(2-methoxy-ethyl) ether / 1.5 h / Heating
3: 94 percent / H+ ion-exchange resin (Amberlyst 15), 4-A molecular sieves / acetonitrile / 4 h / 25 °C
View Scheme
参考文献
Gerth, Dale B.; Giese, Bernd
Journal of Organic Chemistry, 1986 , vol. 51, # 19 p. 3726 - 3729
反应条件
1: 78 percent / NaI, azoisobutyronitrile, Bu3SnH / bis-(2-methoxy-ethyl) ether / 1.5 h / Heating
2: 94 percent / H+ ion-exchange resin (Amberlyst 15), 4-A molecular sieves / acetonitrile / 4 h / 25 °C
View Scheme
参考文献
Gerth, Dale B.; Giese, Bernd
Journal of Organic Chemistry, 1986 , vol. 51, # 19 p. 3726 - 3729
反应条件
1: 89.1 percent / Al(O-i-Pr)3 / propan-2-ol / 2 h / Heating
2: p-TsOH / toluene / Heating
View Scheme
参考文献
Ljubovic; Sunjic
Synthesis, 2001 , # 3 p. 423 - 426
反应条件
1: biocatalytic reduction, enzyme: Yamadazyma farinosa IFO 10896, pH 4.7-4.3
2: p-TsOH / toluene / Heating
View Scheme
参考文献
Sugai, Takeshi; Hamada, Keiji; Akeboshi, Tomohiro; Ikeda, Hajime; Ohta, Hiromichi
Synlett, 1997 , vol. 1997, # 8 p. 983 - 985
反应条件
1: 5N NaOH / ethanol / 5 h / Heating
2: p-TsOH / toluene / Heating
View Scheme
参考文献
Sugai, Takeshi; Hamada, Keiji; Akeboshi, Tomohiro; Ikeda, Hajime; Ohta, Hiromichi
Synlett, 1997 , vol. 1997, # 8 p. 983 - 985
反应条件
1: 92 percent / NiCl2, NaBH4 / methanol / Ambient temperature
2: p-TsOH / methanol / Ambient temperature
3: benzene
View Scheme
参考文献
Fukui, Hideto; Tsuchiya, Yoshinori; Fujita, Keiko; Nakagawa, Tadakiyo; Koshino, Hiroyuki; Nakata, Tadashi
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 16 p. 2081 - 2086
反应条件
1: 1) H2, 2) p-toluenesulfonic acid (PTS) / 1) Ru2Cl4((R)-binap)2(NEt3) / 1) MeOH, 100 atm, 50 deg C, 48 h, 2) toluene, reflux, 2 h
2: H2 / Pd/C
View Scheme
参考文献
Shao, Liming; Kawano, Hiroyuki; Saburi, Masahiko; Uchida, Yasuzo
Tetrahedron, 1993 , vol. 49, # 10 p. 1997 - 2010
反应条件
toluene-4-sulfonic acid in benzene
Heating; Yield given. Yields of byproduct given;
参考文献
Fouque, Elie; Rousseau, Gerard
Synthesis, 1989 , # 9 p. 661 - 666
反应条件
hydrogen; palladium on activated charcoal
Title compound not separated from byproducts;
参考文献
Shao, Liming; Kawano, Hiroyuki; Saburi, Masahiko; Uchida, Yasuzo
Tetrahedron, 1993 , vol. 49, # 10 p. 1997 - 2010
反应条件
toluene-4-sulfonic acid in toluene
Heating; Title compound not separated from byproducts;
参考文献
Ljubovic; Sunjic
Synthesis, 2001 , # 3 p. 423 - 426
