1H-吲唑-3-羧酸甲酯合成路线 （共 31 条）
反应条件
ammonium chloride in N,N-dimethyl-formamide
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1346982 A1, 2003 ;
参考文献
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A.
Patent: WO2008/61688 A1, 2008 ;
Location in patent: Page/Page column 20 ;
WO 2008/061688 A1
反应条件
iodine; sodium hydrogensulfite in dichloromethane
参考文献
US2003/187026 A1, ;
US 20030187026 A1
反应条件
iodine; bis-[(trifluoroacetoxy)iodo]benzene in dichloromethane T=20°C;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 20 p. 6832 - 6846
反应条件
T=100°C; und verseifen des Esters mit alkoh. Alkali;
参考文献
v. Auwers; Dereser
Chemische Berichte, 1919 , vol. 52, p. 1345,1348
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide T=20°C; 2: in water
参考文献
THRESHOLD PHARMACEUTICALS, INC.
Patent: WO2005/120498 A2, 2005 ;
Location in patent: Page/Page column 22 ;
反应条件
1: 1.) tert-BuOK / 1.) THF, 5 deg C, 1 h, 2.) THF, RT, 20 h 2: NaOH View Scheme
参考文献
Harada; Morie; Hirokawa; Terauchi; Fujiwara; Yoshida; Kato
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 11 p. 1912 - 1930
反应条件
sodium ethanolate und Verseifen des Reaktionsgemisches mit alkoh. Kalilauge;
参考文献
v. Auwers; Schaich
Chemische Berichte, 1921 , vol. 54, p. 1744
反应条件
bromine in N,N-dimethyl-formamide T=0 - 20°C; 4 h;
参考文献
Crestey, Francois; Collot, Valerie; Stiebing, Silvia; Lohier, Jean-Francois; Santos, Jana Sopkova-de Oliveira; Rault, Sylvain
Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2457 - 2460
反应条件
tetrahydro-4H-pyran; lithium aluminium tetrahydride
参考文献
Aventis Pharma S.A.
Patent: US2005/9894 A1, 2005 ;
Location in patent: Page 18; 27 ;
US 20050009894 A1
