4-硝基苯基-1,3-二甲酸合成路线 （共 24 条）
反应条件
sulfuric acid; sodium hydrogencarbonate in methanol; water; ethyl acetate
参考文献
Andrianjara, Charles; Ortwine, Daniel Fred; Pavlovsky, Alexander Gregory; Roark, William Howard
Patent: US2003/78276 A1, 2003 ;
US 20030078276 A1
反应条件
thionyl chloride
10 h; Heating / reflux;
参考文献
SoftCure Pharmaceuticals AB
Patent: WO2008/152142 A1, 2008 ;
Location in patent: Page/Page column 25 ;
反应条件
1: concentrated sulfuric acid
3: tin; concentrated hydrochloric acid
View Scheme
参考文献
Axer
Monatshefte fuer Chemie, 1920 , vol. 41, p. 155
反应条件
phosphorus pentachloride; toluene-4-sulfonamide
T=200 - 205°C; 0.5 h;
参考文献
Kornblum, Nathan; Fifolt, Michael J.
Tetrahedron, 1989 , vol. 45, # 5 p. 1311 - 1322
