4,5-二甲基-2-硝基苯甲酸合成路线 （共 5 条）
反应条件
1: With nitric acid
T=0°C; 10 h;
2: With hydrogen; palladium on activated charcoal in methanol
P=2844.31 Torr; 10 h;
参考文献
Atwell, Graham J; Yang, Shangjin; Denny, William A
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 10 p. 825 - 828
反应条件
sulfuric acid; potassium nitrate
T=0°C; 1 h;
参考文献
Courtin, Alfred; Tobel, Hans-Rudolf von
Helvetica Chimica Acta, 1980 , vol. 63, # 2 p. 385 - 394
反应条件
1: (i) NaNO2, aq. HCl, (ii) /BRN= 3587243/, CuCN, aq. Na2CO3, toluene
2: aq. H2SO4
View Scheme
参考文献
Braendstroem,A.; Carlsson,A.I.
Acta Chemica Scandinavica (1947-1973), 1967 , vol. 21, p. 983 - 992
反应条件
1: (i) (nitration), (ii) (hydrolysis)
2: (i) NaNO2, aq. HCl, (ii) /BRN= 3587243/, CuCN, aq. Na2CO3, toluene
3: aq. H2SO4
View Scheme
参考文献
Braendstroem,A.; Carlsson,A.I.
Acta Chemica Scandinavica (1947-1973), 1967 , vol. 21, p. 983 - 992
反应条件
hydrogen; palladium on activated charcoal in acetic acid
参考文献
Braendstroem,A.; Carlsson,A.I.
Acta Chemica Scandinavica (1947-1973), 1967 , vol. 21, p. 983 - 992
