2-(4-氯甲基苯基)丙酸乙酯合成路线 （共 9 条）
反应条件
potassium hydroxide 1.) DMF, RT, 0.5 h, 2.) DMF, 50 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Terada, Atsusuke; Naruto, Shunji; Wachi, Kazuyuki; Tanaka, Shigeru; Iizuka, Yoshio; Misaka, Eiichi
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 212 - 216
反应条件
hydrogenchloride
0.5 h; Ambient temperature;
参考文献
Biagi; Livi; Scartoni; Verugi
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 7-8 p. 597 - 611
反应条件
1: 1.) NaNO2; 2.) K2CO3; 3.) CuCN / 1.) 6M HCl, H2O, 0-5 deg C, 15 min; 2.) 0-5 deg C; 3.) water, 110 deg C, 25 min
2: 57 percent / Raney-alloy / formic acid / 1 h / Heating
3: 88 percent / NaBH4 / methanol; H2O / 20 - 22 °C
4: 92 percent / 12M HCl / 0.5 h / Ambient temperature
View Scheme
参考文献
Biagi; Livi; Scartoni; Verugi
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 7-8 p. 597 - 611
反应条件
1: 88 percent / NaBH4 / methanol; H2O / 20 - 22 °C
2: 92 percent / 12M HCl / 0.5 h / Ambient temperature
View Scheme
参考文献
Biagi; Livi; Scartoni; Verugi
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 7-8 p. 597 - 611
反应条件
1: 57 percent / Raney-alloy / formic acid / 1 h / Heating
2: 88 percent / NaBH4 / methanol; H2O / 20 - 22 °C
3: 92 percent / 12M HCl / 0.5 h / Ambient temperature
View Scheme
参考文献
Biagi; Livi; Scartoni; Verugi
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 7-8 p. 597 - 611
参考文献
Maillard; Langlois; Delaunay; Tri
1973 , vol. 8, # 4 p. 487 - 494
反应条件
potassium hydroxide
1.) xylene, reflux, 10 h, 2.) H2O, EtOH, reflux, 2 h; Yield given. Multistep reaction;
参考文献
Terada, Atsusuke; Naruto, Shunji; Wachi, Kazuyuki; Tanaka, Shigeru; Iizuka, Yoshio; Misaka, Eiichi
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 212 - 216
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane
参考文献
Maillard; Langlois; Delaunay; Tri
1973 , vol. 8, # 4 p. 487 - 494
反应条件
1: hexamethylene tetramine
2: aq. NaHCO3
View Scheme
参考文献
Maillard; Langlois; Delaunay; Tri
1973 , vol. 8, # 4 p. 487 - 494
