5,5-双(溴甲基)-2,2-二甲基-1,3-二氧六环合成路线 （共 5 条）
反应条件
toluene-4-sulfonic acid in acetone 2 h; Ambient temperature;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
Patent: WO2009/10783 A1, 2009 ;
Location in patent: Page/Page column 69 ;
WO 2009/010783 A1
反应条件
toluene-4-sulfonic acid in benzene 12 h; Heating / reflux;
参考文献
Li, Xian-Mei; Fan, Fan; Lu, Jing-Song; Xue, Sai-Feng; Zhang, Yun-Qian; Zhu, Qian-Jiang; Tao, Zhu; Lawrance, Geofferey A.; Wei, Gang
New Journal of Chemistry, 2011 , vol. 35, # 5 p. 1088 - 1095
反应条件
toluene-4-sulfonic acid in water; acetone; benzene
参考文献
Shell Oil Company
Patent: US4701534 A1, 1987 ;
反应条件
1: hydrogenchloride; hydrogen bromide; acetic anhydride / ethanol 2: toluene-4-sulfonic acid / 4 h / 30 °C View Scheme
参考文献
Li, Xian-Mei; Fan, Fan; Lu, Jing-Song; Xue, Sai-Feng; Zhang, Yun-Qian; Zhu, Qian-Jiang; Tao, Zhu; Lawrance, Geofferey A.; Wei, Gang
New Journal of Chemistry, 2011 , vol. 35, # 5 p. 1088 - 1095
反应条件
acetic acid 1 h; Heating;
参考文献
Bitha; Carvajal; Citarella; Delos Santos; Durr; Hlavka; Lang Jr.; Lindsay; Thomas; Wallace; Lin
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2063 - 2067
