1: 4-cyano-3-(trifluoromethyl)phenylisocyanide With titanium tetrachloride in dichloromethane Passerini reaction; 1 h; Cooling with ice; 2: 1-(4-fluorophenylsulfonyl)propan-2-one in dichloromethane Passerini reaction; 3 h; 3: With water in dichloromethane 0.333333 h;