1,2,3,4-四氢-7-甲氧基异喹啉盐酸盐合成路线 （共 17 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Heating;
参考文献
Sall; Grunewald
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2208 - 2216
反应条件
ammonia; sodium in ethanol 1.08333 h;
参考文献
Ashford, Mark E.; Nguyen, Vu H.; Greguric, Ivan; Pham, Tien Q.; Keller, Paul A.; Katsifis, Andrew
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 5 p. 783 - 794
反应条件
hydrogenchloride in diethyl ether
参考文献
Akzo Nobel N.V.
Patent: US6194409 B1, 2001 ;
反应条件
1: With 1-chloroethyl chlorocarbonate; sodium hydrogencarbonate in 1,2-dichloro-ethane Heating; 2: With potassium hydroxide in methanol; 1,2-dichloro-ethane Heating; Further stages.;
参考文献
Cai, Tingwei Bill; Zou, Zhou; Thomas, James B.; Brieaddy, Larry; Navarro, Hernan A.; Carroll, F. Ivy
Journal of Medicinal Chemistry, 2008 , vol. 51, # 6 p. 1849 - 1860
反应条件
sodium hydroxide in ethanol Ambient temperature;
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
1: PPA / 140 °C 2: LAH / tetrahydrofuran View Scheme
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang
Patent: WO2012/97682 A1, 2012 ;
反应条件
1: toluene / Heating 2: aq. H2SO4 / 0 °C 3: H2; AcOH / PtO2 / 20 °C / 2280 Torr View Scheme
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
1: Et3N / tetrahydrofuran 2: PPA / 140 °C 3: LAH / tetrahydrofuran View Scheme
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang
Patent: WO2012/97682 A1, 2012 ;
反应条件
1: 90 percent / H2 / 10percent Pd/C / ethanol / 48 h / 80 °C / 3102.9 Torr 2: 84 percent / LiAlH4 / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Ajao, J. F.; Bird, C. W.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 329 - 331
反应条件
1: SOCl2 / toluene / 3 h / 80 °C 2: NaN3 / m-xylene / 5 h / 120 °C 3: 75 percent / I2 / 1,2-dichloro-benzene / Heating; overnight 4: 90 percent / H2 / 10percent Pd/C / ethanol / 48 h / 80 °C / 3102.9 Torr 5: 84 percent / LiAlH4 / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Ajao, J. F.; Bird, C. W.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 329 - 331
