1,2,3,4-四氢-7-甲氧基异喹啉盐酸盐合成路线 （共 17 条）
反应条件
1: NaN3 / m-xylene / 5 h / 120 °C 2: 75 percent / I2 / 1,2-dichloro-benzene / Heating; overnight 3: 90 percent / H2 / 10percent Pd/C / ethanol / 48 h / 80 °C / 3102.9 Torr 4: 84 percent / LiAlH4 / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Ajao, J. F.; Bird, C. W.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 329 - 331
反应条件
1: 75 percent / I2 / 1,2-dichloro-benzene / Heating; overnight 2: 90 percent / H2 / 10percent Pd/C / ethanol / 48 h / 80 °C / 3102.9 Torr 3: 84 percent / LiAlH4 / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Ajao, J. F.; Bird, C. W.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 329 - 331
参考文献
Fritsch
Justus Liebigs Annalen der Chemie, 1895 , vol. 286, p. 16
Full Text Show Details
Fritsch
Patent: DE85566 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 1149
反应条件
hydrogen bromide T=120°C; 3 h;
参考文献
Sall; Grunewald
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2208 - 2216
反应条件
hydrogenchloride in diethyl ether; ethyl acetate
参考文献
IONIX PHARMACEUTICALS LIMITED
Patent: WO2005/5392 A1, 2005 ;
Location in patent: Page 76 ;
WO 2005/005392 A1
反应条件
1: aq. HBr / 3 h / Heating 2: aq. NaOH / dioxane / 12 h / 20 °C View Scheme
参考文献
Ueno, Hiroshi; Yokota, Katsuyuki; Hoshi, Jun-Ichi; Yasue, Katsutaka; Hayashi, Mikio; Uchida, Itsuo; Aisaka, Kazuo; Hase, Yasunori; Katoh, Susumu; Cho, Hidetsura
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 185 - 189
参考文献
PANACEA BIOTEC LIMITED
Patent: WO2009/118765 A2, 2009 ;
Location in patent: Page/Page column 34-35 ;
WO 2009/118765 A2
