1: N-[5-((1R)-2-bromo-1-hydroxyethyl)-2-(phenylmethoxy)phenyl]carboxamide; (R)-N-benzyl-N-(1-methyl-2-p-methoxyphenylethyl)amine L-mandelate With potassium carbonate in tetrahydrofuran; methanol T=25°C; Inert atmosphere; 2: T=120°C; 24 h; Inert atmosphere; 3: (2E)-but-2-enedioic acid Further stages;

1.1: platinum on carbon; hydrogen / methanol / 20 °C / 2327.23 - 2844.39 Torr / |Inert atmosphere 2.1: methanol / |Inert atmosphere; |Reflux 3.1: potassium carbonate / methanol; tetrahydrofuran / 25 °C / |Inert atmosphere 3.2: 255 / 24 h / 120 °C / |Inert atmosphere View Scheme