1-乙氧基-2,2,2-三氟乙醇合成路线 （共 58 条）
反应条件
toluene-4-sulfonic acid in toluene
2 h; Reflux;
参考文献
Mimura, Hideyuki; Kawada, Kosuke; Yamashita, Tetsuya; Sakamoto, Takeshi; Kikugawa, Yasuo
Journal of Fluorine Chemistry, 2010 , vol. 131, # 4 p. 477 - 486
反应条件
5A molecular sieve in dichloromethane
Substitution; 72 h;
参考文献
Ingrassia, Laurent; Mulliez, Michel
Synthesis, 1999 , # 10 p. 1731 - 1738
反应条件
in ethanol
Heating / reflux;
参考文献
BRYSTOL-MYERS SQUIBB COMPANY
Patent: WO2004/83177 A2, 2004 ;
Location in patent: Page 161-162 ;
WO 2004/083177 A2
反应条件
potassium carbonate
T=23 - 60°C; 28.5 h;
参考文献
Shao, Yi-Ming; Yang, Wen-Bin; Kuo, Tun-Hsun; Tsai, Keng-Chang; Lin, Chun-Hung; Yang, An-Suei; Liang, Po-Huang; Wong, Chi-Huey
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 8 p. 4652 - 4660
反应条件
disulfonyl fluoride; Et3N*2HF; triethylamine in acetonitrile
T=-78 - 20°C;
参考文献
Central Glass Company, Limited
Patent: EP2292579 A1, 2011 ;
Location in patent: Page/Page column 9-10 ;
反应条件
toluene-4-sulfonic acid
T=20°C; Substitution;
参考文献
Shirai, Kimihiro; Onomura, Osamu; Maki, Toshihide; Matsumura, Yoshihiro
Tetrahedron Letters, 2000 , vol. 41, # 31 p. 5873 - 5876
反应条件
zinc(II) chloride
T=130°C; 8 h;
参考文献
Gong; Kato; Kimoto
Bulletin of the Chemical Society of Japan, 2001 , vol. 74, # 2 p. 377 - 383
反应条件
aluminium trichloride in dichloromethane
2.5 h; Ambient temperatureother Lewis acids, other time; Product distribution;
参考文献
Sakumo, Kunihiro; Kuki, Noriko; Kuno, Terumi; Takagi, Toshiyuki; Koyama, Mayumi; Ando, Akira; Kumadaki, Itsumaro
Journal of Fluorine Chemistry, 1999 , vol. 93, # 2 p. 165 - 170
