1-Alpha-氯-3,5-二-O-对甲苯甲酰基-2-脱氧-D-呋喃核糖合成路线 （共 54 条）
反应条件
in tetrahydrofuran; acetonitrile T=4°C; 0.5 h;
参考文献
Shinozuka, Kazuo; Morita, Tsutomu; Hirota, Yoshiki; Sawai, Hiroaki
Chemistry Letters, 1991 , # 11 p. 1941 - 1944
反应条件
in chloroform-d1 48 h;
参考文献
Rolland, Valerie; Kotera, Mitsuharu; Lhomme, Jean
Synthetic Communications, 1997 , vol. 27, # 20 p. 3505 - 3511
反应条件
1: 1.) NaH / 1.) acetonitrile, r.t., 30 min; 2.) 50 deg C, 2 h 2: 61 percent / ammonia / methanol / 12 h / 100 °C 3: 90 percent / K2CO3, hydrogen / 10percent Pd/C / aq. propan-1-ol / 2 h / 1520 Torr View Scheme
参考文献
Kazimierczuk, Zygmunt; Cottam, Howard B.; Revankar, Ganapathi R.; Robins, Roland K.
Journal of the American Chemical Society, 1984 , vol. 106, # 21 p. 6379 - 6382
反应条件
1: 1.) NaH / 1.) CH3CN, 0 deg C, 40 min, 2.) CH3CN, 3 h 2: 99 percent / 1percent methanol. NaOH / 1 h / Ambient temperature 3: 99 percent / H2 / 5percent Pd/C / methanol / 2 h / Ambient temperature 4: pyridine / 0.5 h / 0 °C 5: pyridine / 2.5 h / Ambient temperature 6: sat. aq. NH4OH / 1 h / 0 - 20 °C View Scheme
参考文献
Griffin, Linda C.; Kiessling, Laura L.; Beal, Peter A.; Gillespie, Paul; Dervan, Peter B.
Journal of the American Chemical Society, 1992 , vol. 114, # 21 p. 7976 - 7982
反应条件
1: pyridine / CH2Cl2 / 1 h / Ambient temperature 2: 95 percent / Pd(Ph3P)4 / toluene / 7 h / Heating 3: 85 percent / 0.1 M NaOMe / methanol / 2 h / Ambient temperature View Scheme
参考文献
Wigerinck, P.; Pannecouque, C.; Snoeck, R.; Claes, P.; Clercq, E. De; Herdewijn, P.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2383 - 2389
反应条件
sodium hydride 1) acetonitrile, RT, 30 min; 2) acetonitrile, 18 h; Yield given. Multistep reaction;
参考文献
Hanna; Ramasamy; Robins; Revankar
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1899 - 1903
反应条件
potassium hydroxide; tri[2-(2-methoxyethoxy)ethyl]amine 1) MeCN, r.t.; Yield given. Multistep reaction;
参考文献
Brown; Lin
Carbohydrate Research, 1991 , vol. 216, p. 129 - 139
反应条件
1.) acetonitrile, THF, 10 deg C, 40 min, 2.) acetonitrile, THF, 10 deg C, 10 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Shinozuka, Kazuo; Hirota, Yoshiki; Morita, Tsutomu; Sawai, Hiroaki
Heterocycles, 1992 , vol. 34, # 11 p. 2117 - 2121
反应条件
1.1: NaH / acetonitrile / 0.5 h / 20 °C 1.2: 50 percent / acetonitrile 2.1: 93 percent / NaOH / methanol / 0.83 h / 20 °C 3.1: 97 percent / aq. methanol / 15 h / Irradiation View Scheme
参考文献
Kotera, Mitsuharu; Roupioz, Yoann; Defrancq, Eric; Bourdat, Anne-Gaelle; Garcia, Julian; Coulombeau, Christian; Lhomme, Jean
Chemistry - A European Journal, 2000 , vol. 6, # 22 p. 4163 - 4169
反应条件
1: 1.) NaH / 1.) acetonitrile, r.t., 30 min; 2.) 15 h 2: 78 percent / ammonia / methanol / 12 h / 100 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 21 p. 6379 - 6382
