1-Alpha-氯-3,5-二-O-对甲苯甲酰基-2-脱氧-D-呋喃核糖合成路线 （共 54 条）
反应条件
1: 20 percent / KOH, TDA-1 / acetonitrile / 0.5 h / Ambient temperature
2: 84 percent / NH3 / methanol / 72 h / 50 °C
3: 98 percent / adenosine deaminase / H2O / Ambient temperature
View Scheme
参考文献
Seela; Lampe
Helvetica Chimica Acta, 1993 , vol. 76, # 6 p. 2388 - 2397
反应条件
1: 37 percent / KOH, tris-<2-(2-methoxyethoxy)ethyl>amine / acetonitrile / 0.33 h / Ambient temperature
2: 79 percent / NaOMe / methanol / 0.5 h / Ambient temperature
View Scheme
参考文献
Seela, Frank; Leonard, Peter
Helvetica Chimica Acta, 1997 , vol. 80, # 4 p. 1301 - 1318
反应条件
2: 80 percent / NH3 / methanol / 24 h / Ambient temperature
View Scheme
参考文献
Seela, Frank; Bindig, Uwe
Liebigs Annalen der Chemie, 1989 , p. 895 - 902
反应条件
1: 1.) KOH / 1.) tris-<2-(2-methoxyethoxy)ethyl>amine / 1.) MeCN, room temp., 5 min, 2.) room temp., 15 min
2: 84 percent / NH3 / methanol / 24 h / Ambient temperature
3: 78 percent / pyridine, N,N-diisopropylethylamine / 3 h / Ambient temperature
4: 76 percent / 4-dimethylaminopyridine / acetonitrile / 16 h / Ambient temperature
5: 75 percent / n-Bu3SnH, 2,2'-azobis(2-methyl)propionitrile / toluene / 2 h / 75 °C
6: 67 percent / 80percent aq. AcOH / 0.5 h / Ambient temperature
7: 65 percent / 25percent aq. NH3 / 15 h / 100 °C
View Scheme
参考文献
Seela; Muth; Bindig
Synthesis, 1988 , # 9 p. 670 - 674
